24320-06-7Relevant articles and documents
Steroids 51. An improved synthesis of ORG 2058 and the synthesis of [3H]ORG 2058
Bakos, Tamas,Lokoes, Magdalena,Vincze, Iren,Volford, Janos
, p. 115 - 118 (1993)
16α-Ethyl-21-hydroxy-19-norpregn-4-ene-3,20-dione (ORG 2058) is a ligand widely used in progesterone receptor assays. An improved synthesis of the compound is reported, starting from norethisterone acetate. The preparation of the tritiated radioligand [3H]ORG 2058 is also described. (Steroids 58:115-118, 1993).
Steroids 48. Synthesis of 16α-ethyl-21-hydroxy-19-norpregn-4-ene-3,20-dione from 17-substituted 3-methoxyestradiols
Lokoes, Magdalena,Bakos, Tamas,Vincze, Iren
, p. 185 - 189 (2007/10/02)
A new synthesis of 16α-ethyl-21-hydroxy-19-norpregn-4-ene-3,20-dione is described, starting from 17-cyano- and 17α-ethynyl-3-methoxyestra-1,3,5-(10)-trien-17-ols.Keywords: steroids; synthesis; 19-norpregnenes; A-aromatic pregnenes