24326-89-4Relevant articles and documents
Toward the development of a general chiral auxiliary. 9. Highly diastereoselective alkylations and acylations to form tertiary and quaternary centers.
Boeckman Jr.,Boehmler,Musselman
, p. 3777 - 3780 (2007/10/03)
[reaction--see text] Enolates of a new camphor-derived lactam auxiliary are shown to monoalkylate with very high diastereoselectivity. A second alkylation occurs with reactive alkylating agents to afford quaternary centers also with high diastereoselectiv