24332-99-8

Usage

Uses

Used in Biochemical Research:
p-nitrophenyl 2,3,4-tri-O-acetyl-β-L-fucopyranoside is used as a synthetic substrate for the detection and quantification of α-L-fucosidase activity in laboratories, aiding in the study of enzyme kinetics and mechanisms.
Used in Pharmaceutical Research and Development:
p-nitrophenyl 2,3,4-tri-O-acetyl-β-L-fucopyranoside is employed in the development and testing of potential α-L-fucosidase inhibitors for the treatment of diseases such as cancer and liver diseases, which involve aberrant fucosylation, playing a critical role in the study and development of potential therapeutic agents targeting α-L-fucosidase-related pathologies.

Upstream product

• 100-02-7 4-nitro-phenol 
• 16741-27-8 2,3,4-tri-O-acetyl-α-L-fucopyranosyl bromide 
• 73-34-7 6-deoxy-L-galactose 
• 7404-35-5 1,2,3,4-tetra-O-acetyl-L-fucopyranose 

Downstream Products

• 22153-71-5 1-(4-nitrophenyl)-β-L-fucopyranoside 

Relevant academic research and scientific papers

Glycosynthase with broad substrate specificity-an efficient biocatalyst for the construction of oligosaccharide library

A versatile glycosynthase (TnG-E338A) with strikingly broad substrate scope has been developed from Thermus nonproteolyticus β-glycosidase (TnG) by using site-directed mutagenesis. The practical utility of this biocatalyst has been demonstrated by the facile generation of a small library containing various oligosaccharides and a steroidal glycoside (total 25 compounds) in up to 100 % isolated yield. Moreover, an array of eight gluco-oligosaccharides has been readily synthesized by the enzyme in a one-pot, parallel reaction, which highlights its potential in the combinatorial construction of a carbohydrate library that will assist glycomic and glycotherapeutic research. Significantly, the enzyme provides a means by which glycosynthase technology may be extended to combinatorial chemistry.

A straightforward α-selective aromatic glycosylation and its application for stereospecific synthesis of 4-methylumbelliferyl α-T-antigen

A practical and efficient α-selective aromatic glycosylation with simple per-O-acetyl glycopyranosyl trichloroacetimidates is reported. The method is particularly effective for L-fucosyl and 2-azido-2-deoxy-d-galatosaminyl imidates, with which exclusive α-selectivity was achieved. The synthetic utility of this method was demonstrated in the stereoselective synthesis of 4-methylumbelliferyl α-T-antigen.