243445-17-2

Upstream product

• 1125-99-1 1-(1-Cyclohexen-1-yl)pyrrolidine 
• 25287-79-0 3-dimethylamino-1,2-diphenyl-propan-1-one hydrochloride 
• 3923-51-1 1,1-diphenylprop-2-en-1-ol 
• 108-94-1 cyclohexanone 
• 451-40-1 phenyl benzyl ketone 

Downstream Products

• 82132-58-9 2,3-diphenyl-5,6,7,8-tetrahydroquinoline 

Relevant academic research and scientific papers

Metal-free oxidative radical addition of carbonyl compounds to a,a-Diaryl allylic alcohols: Synthesis of highly functionalized Ketones

A metal-free direct alkylation of simple carbonyl compounds (ketones, esters, and amides) with a,a-diaryl allylic alcohols is described. The protocol provides facile access to highly functionalized dicarbonyl ketones by a radical addition/1,2-aryl migration cascade. The regioselectivity of the reaction was precisely controlled by the nature of the carbonyl compound.

Efficient Preparation of Substituted 5,6,7,8-Tetrahydroquinolines and Octahydroacridine Derivatives

The reaction of the enamine 4 with different β-amino ketone hydrochlorides 3a-e affords the diketones 5a-e which can be cyclized to the corresponding mono- and disubstituted tetrahydroquinolines 6a-e. Furthermore the preparation of the octahydroacridines 8f and 8g by using a straightforward multi step sequence is described.