243456-15-7Relevant academic research and scientific papers
Thiadiazolium ylides: Substituted 2H-1,3,5-thiadiazines and 1,4,5-trisubstituted-imidazoles from 1,2,4- and 1,2,5-thiadiazolium-2-unsubstituted methanide (ylide) systems: Ring expansions and ring interconversions via sulfur-nitrogen heterotriene intermediates. Mechanistic ab initio calculations. Azolium 1,3-dipoles
Butler, Richard N.,Cloonan, Martin O.,McMahon, John M.,Burke, Luke A.
, p. 1709 - 1712 (1999)
Quaternisation of 3,5-diaryl-1,2,4-thiadiazoles with trimethylsilylmethyl triflate at 40°C occurred at N-2. Separate desilylation of the salts resulted in a ring expansion to substituted 2H-1,3,5-thiadiazines 5. Heating of these with ethanolic sodium ethoxide caused sulfur extrusion and ring contraction to 2,4-disubstituted imidazoles 6. 3,4-Diaryl-1,2,5-thiadiazoles were less reactive to alkylation and trimethylsilylmethylation required heating at 80°C. Treatment of the salts with CsF unexpectedly gave 1-trimethylsilylmethyl-4,5-diarylimidazoles 21.1H, 13C, 15N NMR spectra are described and the mechanisms were studied by ab inito calculations with the GAUSSIAN94 series of programmes using the HF/6-31G* theoretical level.
