243469-62-7Relevant articles and documents
Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs
Hanessian, Stephen,Simard, Daniel,Bayrakdarian, Malken,Therrien, Eric,Nilsson, Ingemar,Fjellstroem, Ola
, p. 1972 - 1976 (2008/12/22)
Guided by available X-ray crystal structure data on the serine protease thrombin, a series of pyridin-2-one derivatives were designed and synthesized having diverse functionality at the P1 and P3 sites. Potent in vitro activity again
Studies on the preparation of 3,4-disubstituted 2-methoxypyridines
Pelisson, Marcelo M. M.,Da Silva, Gil Valdo Jose,Clive, Derrick L. J.,Coltart, Don M.,Hof, Fraser A.
, p. 653 - 658 (2007/10/03)
The synthesis of 2-methoxy-4-methylpyridine-3-carbonitrile (3) and its conversion, by way of alkylation of the C(4) methyl group, into the pyridyl acetic acid ester 6 is described.