65169-38-2

Basic information

• Product Name: 2-Chloro-4-methylpyridine-3-carbonitrile
• Synonyms: 2-Chloro-4-methylpyridine-3-carbonitrile;2-chloro-4-methylnicotinonitrile;2-Chloro-4-methyl-3-cyano-pyridine
• CAS NO: 65169-38-2
• Molecular Formula: C₇H₅ClN₂
• Molecular Weight: 152.58
• Product Categories: Boron, Nitrile, Thio,& TM-Cpds;Heterocycles;Pyridine
• Mol File: 65169-38-2.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 286.365oC at 760 mmHg
• Flash Point: 126.989oC
• Appearance: /
• Density: 1.269g/cm3
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.555
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-Chloro-4-methylpyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-methylpyridine-3-carbonitrile(65169-38-2)
• EPA Substance Registry System: 2-Chloro-4-methylpyridine-3-carbonitrile(65169-38-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 65169-38-2(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-methylpyridine-3-carbonitrile is a specialized chemical compound has the molecular formula C7H5ClN2. It typically appears as an off-white solid at room temperature. 2-Chloro-4-methylpyridine-3-carbonitrile belongs to the category of organic compounds known as pyridinecarboxylic acids and derivatives. These are compounds containing a pyridine ring bearing a carboxylic acid group or a derivative thereof. 2-Chloro-4-methylpyridine-3-carbonitrile is often used in the production of other chemicals and compounds in a laboratory or industrial setting. Since this is a chemical, it should be handled with care, taking all necessary precautions and safety measures.

InChI:InChI=1/C7H5ClN2/c1-5-2-3-10-7(8)6(5)4-9/h2-3H,1H3

Upstream product

• 5444-02-0 2,6-dihydroxy-3-cyano-4-methylpyrimidine 
• 875-35-4 2,6-dichloro-4-methylnicotinonitrile 
• 67-56-1 methanol 
• 41125-09-1 3-oxo-butyraldehyde; sodium enolate 
• 109-77-3 malononitrile 
• 71493-72-6 2-(4-(dimethylamino)but-3-en-2-ylidene)malononitrile 
• 13166-10-4 isopropylidenemalonodinitrile 
• 93271-59-1 1,2-dihydro-2-oxo-4-methylpyridine-3-carbonitrile 
• 93271-59-1 2-hydroxy-4-methylpyridine-3-carbonitrile 

Downstream Products

• 149379-71-5 2-methoxy-4-methylpyridine-3-carbonitrile 
• 243469-62-7 3-hydroxymethyl-2-methoxy-4-methylpyridine 
• 243469-67-2 4-(2-hydroxy-2-phenylethyl)-2-methoxypyridine-3-carbonitrile 
• 243469-68-3 methanesulfonic acid 2-(3-cyano-2-methoxy-pyridin-4-yl)-1-phenyl-ethyl ester 
• 243469-77-4 methyl 2-<3-<<<(1,1-dimethylthyl)dimethylsilyl>oxy>methyl>-2-methoxypyrid-4-yl>-2-<(phenoxy)thiocarbonyloxy>ethanoate 
• 152362-01-1 2-chloro-4-methyl-3-pyridinecarboxamide 
• 133627-45-9 3-Amino-2-chloro-4-methylpyridine 
• 498580-78-2 4-methyl-1H-pyrazolo[3,4-b]pyridin-3-amine 
• 1698293-93-4 4-methyl-2-(1-methylethyl)-3-pyridinamine 
• 133627-47-1 N-(2-chloro-4-methyl-3-pyridinyl)-2-(cyclopropylamino)-3-pyridinecarboxamide 
• 129618-40-2 Nevirapine 

Relevant articles and documents

Preparation method of Sotorasib intermediate

The invention discloses a preparation method of a Sotorasib intermediate 2-isopropyl-3-amino-4-methylpyridine. The preparation method comprises the following specific steps of: (1) carrying out a reaction on 3-cyano-4-methyl-2-pyridone and a halogenating reagent to obtain 2-halogenated-3-cyano-4-methylpyridine; (2) making the 2-halogenated-3-cyano-4-methylpyridine with an isopropyl Grignard reagent under the action of a catalyst, so as to obtain 2-isopropyl-3-cyano-4-methylpyridine; (3) carrying out hydrolysis on the 2-isopropyl-3-cyano-4-methylpyridine, so as to obtain 2-isopropyl-4-methyl nicotinamide; and (4) carrying out Hofmann rearrangement on the 2-isopropyl-4-methyl nicotinamide, sodium hydroxide and a sodium hypochlorite solution, so as to obtain the 2-isopropyl-3-amino-4-methylpyridine. The preparation method disclosed by the invention is low in cost and simple to operate, and is a novel method for synthesizing the 2-isopropyl-3-amino-4-methylpyridine.

HETEROCYCLIC COMPOUNDS AS EP4 RECEPTOR ANTAGONISTS

The present invention provides a compound represented by the formula (1): wherein each symbol is as defined in the specification or a salt thereof has an EP4 receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of EP4 receptor associated diseases (e.g., rheumatoid arthritis, aortic aneurysm, endometriosis, ankylosing spondylitis, inflammatory breast cancer etc.) and the like.

LOWCOST, HIGH YIELD SYNTHESIS OF NEVIRAPINE

Improved methods of producing the HIV drug substance, nevirapine are provided. The methods employ a cost effective and high yield synthetic methods for preparing the nevirapine building block 2-chloro-3-amino-4-picoline (CAPIC) and 2-cyclopropyl amino nicotinate (Me-CAN), and improvements in other steps of nevirapine synthesis.