24350-72-9

Upstream product

• 118-55-8 phenyl Salicylate 
• 109-76-2 Trimethylenediamine 
• 119-36-8 methyl salicylate 
• 24350-74-1 N,N'-bis(2-hydroxybenzoyl)-1,3-diaminopropane 
• 118-61-6 2-hydroxy-benzoic acid ethyl ester 
• 61141-14-8 anionic phenyl salicylate 

Relevant academic research and scientific papers

Geometric selectivity, hydrogen-bonding interaction, and solvatochromism of Bis{N-(aminoalkyl)salicylamidato(2-)}cobaltate(III)

Cobalt(III) complexes with N-(aminoalkyl)salicylamide dianions, Ln 2- (n = 14), have been prepared and their molecular and crystal structures have been determined. The geometric (mer- or fac-) selectivity of [Co(Ln)2]- com

Creating capsules with cubanes

A sextuply linked capsule incorporating two Ni(ii) cubane units is formed when Ni(ii) salts are reacted with N-aminoalkyl salicylamidato ligands in a 4:3 ratio in methanol. With a short (propyl) alkyl substituent, additional chloride counter ions are incl

Hydrogen-bonding interactions, geometrical selectivity and spectroscopic properties of cobalt(III) complexes with unsymmetrical tridentate amine-amidato-phenolato type ligands

Four cobalt(III) complexes with the formula of [Co(Ln)2] - bearing tridentate amine-amidato-phenolato-type ligands (Ln: n = 1-4) were synthesized. All of the complexes were characterized by 1H NMR spectroscopy and X-ray an

Proximity effect on the general base catalysed hydrolysis of amide linkage: The role of cationic surfactant, CTABr

The bis phenoxide forms of (1,2) bis(2-hydroxybenzamido) ethane(I) , (1,5) bis(2-hydroxybenzamido) 3-azapentane(II) , (1,3) bis(2-hydroxybenzamido) propane(III) , and (1,8) bis(2-hydroxybenzamido) 3,6- diazaoctane(IV) undergo facile hydrolysis of one of the amide groups (0.02 ≤ [OH?]T (mol dm? 3) ≤ 0.5, 10% MeOH (v/v) + H2O medium) without exhibiting [OH?] dependence. The reactivity trend follows I ～ II >> III ～ IV with low activation enthalpy {25.7±2.8 ≤ δH≠ (kJ mol?1) ≤ 64.8±7.0}. The high negative and comparable values of activation entropy{?234 ±8 ≤ δS≠ (J K?1 mol? 1) ≤ ?127 ± 20} are consistent with closely similar, and ordered transition states which can be assembled by favourably oriented phenoxide groups. The solvent kinetic isotope effect for I, κ H2O/κ D2O+H2O ～ 1 (20 and 50 volume% D2O) , indicates that proton transfer is not involved as a part of the rate controlling process. The observed slowing down of the rate of this reaction for I in the micellar pseudo phase of CTABr also supports the proposed mechanism. Under premicellar conditions, however, rate acceleration is observed, a consequence believed to be associated with the capping effect of the hydrophobic tail of the surfactant cation forming the reactive ion-pair, CTA+, (I-2H) 2? exclusively in the aqueous pseudo phase. Indian Academy of Sciences.

Synthesis, antibacterial activities and molecular docking studies of peptide and Schiff bases as targeted antibiotics

A series of peptide and Schiff bases (PSB) were synthesized by reacting salicylic acid, primary diamines with salicylaldehyde or its derivatives, and 40 of which were newly reported. The inhibitory activities against Escherichia coli β-ketoacyl-acyl carrier protein synthase III (ecKAS III) were investigated in vitro and molecular docking simulation also surveyed. Top 10 PSB compounds which posses both good inhibitory activity and well binding affinities were picked out, and their antibacterial activities against Gram-negative and Gram-positive bacterial strains were tested, expecting to exploit potent antibacterial agent with broad-spectrum antibiotics activity. The results demonstrate compound N-(3-(5-bromo-2-hydroxybenzylideneamino)propyl)-2-hydroxybenzamide (2d) can be as a potential antibiotics agent, displaying minimal inhibitory concentration values in the range of 0.39-3.13 μg/mL against various bacteria. Crown Copyright

Effects of mixed H2O-CH3CN solvents on the Bronsted coefficient for the intramolecular general base-catalyzed cleavage of ionized phenyl salicylate in the presence of primary and secondary amines

Nucleophilic second-order rate constants, knms, for the reactions of several primary and secondary amines with ionized phenyl salicylate (PS-) show a nonlinear decrease with the increase in the content of CH3CN from 2 to ≤50% v/v in mixed aqueous solvent. The values of knms remain almost unchanged with the change in the content of CH3CN at >50% v/v. The nucleophilic reactivity of primary and secondary amines toward PS- reveal Bronsted plots of different Bronsted coefficients, βnuc, at a constant content of CH3CN in mixed aqueous solvents. The values of βnuc decrease from 0.4 to nearly 0 for primary amines and from 0.22 to 0.12 for secondary amines with the increase in CH3CN content from 2 to 70% v/v. The values of knms/kMeOHms (where kMeOHms represents the nucleophilic second-order rate constant for the reaction of MeOH with PS- in H2O-CH3CN solvents), obtained within 2-50% v/v CH3CN, fit to an empirical equation: log (knms/kMeOHms) = θ+λX where X is the % v/v content of CH3CN, and θ and λ are empirical constants. It has been shown empirically that both θ and λ are the function of Bronsted coefficient βlg. The values of λ are used to calculate βlg and these βlg values for all amines except Tris lie within -0.32 to -0.46. The effects of mixed water-acetonitrile solvents on pKa of leaving the group, phenol, and conjugate acid of amine nucleophile have been concluded to be the major source for the observed solvent effects on knms. The βlg for Tris is unusually very close to zero.

Intramolecular General Base Catalysis and the Rate-determining Step in the Nucleophilic Cleavage of Ionized Phenyl Salicylate with Primary and Secondary Amines

The nucleophilic second-order rate constants for the reactions of ionized phenyl salicylate (PS-) with primary and secondary amines have revealed Broensted plots of slopes βnuc1 = 0.52+/-0.06 and βnuc2 = 0.27+/-0.05, respectively.The suggested stepwise reaction mechanism involves the intramolecular proton transfer from cationic nitrogen to the anionic phenolic oxygen to form the monoanionic tetrahedral addition intermediate as the rate-determining step.The low value of βnuc2 is attributed to the extensive of proton transfer in the late transition state while the large value of βnuc1 is ascribed to the proton transfer in the early transition state of the rate-determining step.However, these low and high values of βnuc2 and βnuc1, respectively, are also compatible with the occurence of respective early and late transition states in the rate-determining step involving concerted intramolecular general base-catalysed nucleophilic attack at the carbonyl carbon of PS-.Significantly large positive deviations from Broensted plots have been observed for the reactivities of α-nucleophiles toward PS-.Monoprotonated ethane-1,2-diamine is ca. 20-fold more reactive than would be expected from its basicity, and this is attributed to the occurence of the intramolecular general acid catalysis.The reactions of PS- with hydroxylamine and N-methylhydroxylamine involve ca. >/=70 percent aminolysis and -.