24364-03-2

Upstream product

• 20797-48-2 (E)-4-chloro-3-nitrocinnamic acid 
• 42174-78-7 (E)-ethyl 3-(4-chloro-3-nitrophenyl)acrylate 

Relevant academic research and scientific papers

Receptor-based design of novel dihydrofolate reductase inhibitors: Benzimidazole and indole derivatives

Although many thousands of inhibitors of the enzyme dihydrofolate reductase (DHFR) have been synthesized, all of the very active compounds have been 2,4-diaminopyrimidines or very close analogues. This paper describes 2,4-diamino-6-benzylbenzimidazole (3b