243641-02-3Relevant academic research and scientific papers
Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin αvβ3) antagonists
Miller, William H.,Manley, Peter J.,Cousins, Russell D.,Erhard, Karl F.,Heerding, Dirk A.,Kwon, Chet,Ross, Stephen T.,Samanen, James M.,Takata, Dennis T.,Uzinskas, Irene N.,Yuan, Catherine C. K.,Haltiwanger, R. Curtis,Gress, Catherine J.,Lark, Michael W.,Hwang, Shing-Mei,James, Ian E.,Rieman, David J.,Willette, Robert N.,Yue, Tian-Li,Azzarano, Leonard M.,Salyers, Kevin L.,Smith, Brian R.,Ward, Keith W.,Johanson, Kyung O.,Huffman, William F.
, p. 1483 - 1486 (2007/10/03)
In our continuing efforts to identify small molecule vitronectin receptor antagonists, we have discovered a series of phenylbutyrate derivatives, exemplified by 16, which have good potency and excellent oral bioavailability (approximately 100% in rats). T
