243668-26-0

Basic information

• Product Name: Ethanone, 1-(1-ethyl-1H-benzimidazol-2-yl)- (9CI)
• Synonyms: Ethanone, 1-(1-ethyl-1H-benzimidazol-2-yl)- (9CI);1-(1-ethyl-1H-1,3-benzodiazol-2-yl)ethan-1-one
• CAS NO: 243668-26-0
• Molecular Formula: C₁₁H₁₂N₂O
• Molecular Weight: 188.22578
• Product Categories: BENZIMIDAZOLE
• Mol File: 243668-26-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 1-(1-ethyl-1H-benzimidazol-2-yl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(1-ethyl-1H-benzimidazol-2-yl)- (9CI)(243668-26-0)
• EPA Substance Registry System: Ethanone, 1-(1-ethyl-1H-benzimidazol-2-yl)- (9CI)(243668-26-0)

Safety Data

• Hazardous Substances Data: 243668-26-0(Hazardous Substances Data)

Upstream product

• 74-96-4 ethyl bromide 
• 939-70-8 2-acetylbenzimidazole 
• 95-54-5 1,2-diamino-benzene 
• 16414-04-3 1-benzimidazol-2-ylethanol 
• 299936-69-9 N-ethyl-2-(α-hydroxyethyl)benzimidazole 
• 64-67-5 diethyl sulfate 

Downstream Products

• 1021422-11-6 C₁₇H₁₈N₄ 

Relevant articles and documents

Compositions containing five-membered unsaturated heterocyclic structure of the α, β unsaturated ketone compound and its preparation method and application

The invention provides alpha, beta unsaturated ketone compounds containing benzo five-membered unsaturated heterocycle structures as well as a preparation method and an application and use of the compounds. The alpha, beta unsaturated ketone compounds containing the benzo five-membered unsaturated heterocycle structures have the structure of a formula (I). In addition, the invention further provides a method for preparing the compounds and a pharmaceutical composition containing the components as active components. In vitro activity tests show that the compounds provided by the invention show a remarkable inhibiting effect on tumor cells. Therefore, the invention lays a foundation for lucubrating and developing anti-tumor medicines in the future and meanwhile further provides a new technical means for treating tumor diseases.

A green and simple synthesis of N-alkyl-2-acetylbenzimidazoles

A green and simple synthesis of N-alkyl-2-substituted benzimidazoles has been developed. In this method, 2-acetyl benzimidazole compound (1) was alkylated with reagents such as dimethyl sulfate/diethyl sulfate/benzyl chloride under green conditions i.e., by physical grinding in presence of a mild base like K2CO3 or by using green solvents like PEG-600, ethanol etc. or by using micro-wave irradiation technique to obtain N-alkyl-2-acetylbenzimidazoles compound (2).

Synthesis of novel benzimidazole β-keto sulfones and β-hydroxy sulfones and their regiospecific alkylation studies

The synthesis of benzimidazole β-keto sulfides 5a-f by the reaction of W-alkyl-α-bromo-2-acetylberizirnidazoles 3a-b with 5-substituted- benzimidazole-2-thiols 4a-c followed by successive oxidation with H 2O2 to give β-keto sulfones 8a-f and reduction with NaBH4 to give β-hydroxy sulfones 9a-f is described. Reaction of 5a, 8a, 9a and 10a with DMS in the presence of K2CO3 and TBAB as PTC, resulted in the regiospecific N-methylation of benzimidazole moiety of 12a, 11a, 14a and 13a respectively.