24372-49-4

Basic information

• Product Name: 5-MORPHOLIN-4-YLTHIOPHENE-2-CARBALDEHYDE
• Synonyms: 5-MORPHOLIN-4-YLTHIOPHENE-2-CARBOXALDEHYDE;5-MORPHOLINO-2-THIOPHENECARBALDEHYDE;OTAVA-BB BB7119710109;5-Morpholin-4-ylthiophene-2-carboxaldehyde 97%;2-Formyl-5-(morpholin-4-yl)thiophene;5-Morpholinothiophene-2-carbaldehyde;5-morpholino-2-thiophenecarboxaldehyde;5-(Morpholin-4-yl)thiophene-2-carboxaldehyde97%
• CAS NO: 24372-49-4
• Molecular Formula: C₉H₁₁NO₂S
• Molecular Weight: 197.25
• Mol File: 24372-49-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 126 °C
• Boiling Point: 382 °C at 760 mmHg
• Flash Point: 184.8 °C
• Appearance: /
• Density: 1.281 g/cm³
• Vapor Pressure: 4.86E-06mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: 2-8°C
• PKA: 1.49±0.20(Predicted)
• CAS DataBase Reference: 5-MORPHOLIN-4-YLTHIOPHENE-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-MORPHOLIN-4-YLTHIOPHENE-2-CARBALDEHYDE(24372-49-4)
• EPA Substance Registry System: 5-MORPHOLIN-4-YLTHIOPHENE-2-CARBALDEHYDE(24372-49-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 24372-49-4(Hazardous Substances Data)

Usage

General Description

5-MORPHOLIN-4-YLTHIOPHENE-2-CARBALDEHYDE is a chemical compound that consists of a morpholine group attached to a thiophene ring with a carbaldehyde functional group at the 2-position. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity and potential for creating new molecular structures. The morpholine group provides a basic and polar functionality, while the thiophene ring adds aromatic and electron-rich properties, making the compound useful in various chemical reactions and as a precursor for creating more complex organic compounds. Additionally, the carbaldehyde functional group allows for further derivatization and modification, making 5-MORPHOLIN-4-YLTHIOPHENE-2-CARBALDEHYDE a valuable tool in chemical research and drug discovery.

InChI:InChI=1/C9H11NO2S/c11-7-8-1-2-9(13-8)10-3-5-12-6-4-10/h1-2,7H,3-6H2

Upstream product

• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 110-91-8 morpholine 

Downstream Products

• 332345-27-4 5-(4-morpholinyl)thiophene-2-carboxylic acid 

Relevant articles and documents

Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases

There is interest in developing potent, selective, and cell-permeable inhibitors of human ferrous iron and 2-oxoglutarate (2OG) oxygenases for use in functional and target validation studies. The 3-component Betti reaction enables efficient one-step C-7 functionalisation of modified 8-hydroxyquinolines (8HQs) to produce cell-active inhibitors of KDM4 histone demethylases and other 2OG oxygenases; the work exemplifies how a template-based metallo-enzyme inhibitor approach can be used to give biologically active compounds.

BCRP/ABCG2 INHIBITOR

The present invention is directed to a breast cancer resistance protein (BCRP/ABCG2) inhibitor. The BCRP inhibitor contains, as an active ingredient, an acrylonitrile derivative represented by formula (1): wherein one of R1 and R2 re

Efficient synthesis of N,N-disubstituted 5-aminothiophene-2-carboxaldehydes by nucleophilic aromatic substitution in water

We have developed the first synthesis of N,N-disubstituted 5-aminothiophene-2-carboxaldehydes by Nucleophilic Aromatic Substitution of 5-bromothiophene-2-carboxaldehyde in water. This study shows selectivity between primary and secondary amines leading to