24372-49-4

Usage

Uses

Used in Pharmaceutical Industry:
5-MORPHOLIN-4-YLTHIOPHENE-2-CARBALDEHYDE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to create new molecular structures with potential therapeutic properties. The morpholine group provides basic and polar functionality, while the thiophene ring contributes aromatic and electron-rich characteristics, facilitating the development of innovative drug candidates.
Used in Agrochemical Industry:
In the agrochemical sector, 5-MORPHOLIN-4-YLTHIOPHENE-2-CARBALDEHYDE is utilized as a precursor in the synthesis of novel agrochemicals, such as pesticides and herbicides. Its versatile reactivity and potential for creating complex organic compounds make it a valuable component in the development of effective and environmentally friendly agricultural products.
Used in Chemical Research:
5-MORPHOLIN-4-YLTHIOPHENE-2-CARBALDEHYDE is employed as a valuable tool in chemical research for its potential to participate in various chemical reactions and undergo further derivatization and modification. The carbaldehyde functional group allows for the attachment of different chemical moieties, enabling the exploration of new chemical pathways and the discovery of novel compounds with unique properties.
Overall, 5-MORPHOLIN-4-YLTHIOPHENE-2-CARBALDEHYDE's diverse applications across different industries highlight its significance as a versatile and valuable chemical compound in modern science and technology.

InChI:InChI=1/C9H11NO2S/c11-7-8-1-2-9(13-8)10-3-5-12-6-4-10/h1-2,7H,3-6H2

Upstream product

• 110-91-8 morpholine 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 

Downstream Products

• 332345-27-4 5-(4-morpholinyl)thiophene-2-carboxylic acid 

Relevant academic research and scientific papers

Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases

There is interest in developing potent, selective, and cell-permeable inhibitors of human ferrous iron and 2-oxoglutarate (2OG) oxygenases for use in functional and target validation studies. The 3-component Betti reaction enables efficient one-step C-7 functionalisation of modified 8-hydroxyquinolines (8HQs) to produce cell-active inhibitors of KDM4 histone demethylases and other 2OG oxygenases; the work exemplifies how a template-based metallo-enzyme inhibitor approach can be used to give biologically active compounds.

A facile preparation of trisubstituted amino-furan and -thiophene derivatives

β-Alkylation of amino-furan and -thiophene heterocycles is described through metal-, acid- and base-free carbon-carbon bond formation. The ability of both heterocycles to undergo selective β-alkylation is compared by mean of experimental and theoretical data. The presence of chiral amine substituents induced the diastereoselective generation of the newly formed additional stereocenter.

BCRP/ABCG2 INHIBITOR

The present invention is directed to a breast cancer resistance protein (BCRP/ABCG2) inhibitor. The BCRP inhibitor contains, as an active ingredient, an acrylonitrile derivative represented by formula (1): wherein one of R1 and R2 re

Convenient amination of weakly activated thiophenes, furans and selenophenes in aqueous media

We describe herein a new amination procedure of weakly activated heterocyclic bromo derivatives in aqueous media. The base catalysed mechanism of this reaction is also confirmed. Moreover, the application of this strategy to the preparation of amino furans and selenophenes is outlined.

Efficient synthesis of N,N-disubstituted 5-aminothiophene-2-carboxaldehydes by nucleophilic aromatic substitution in water

We have developed the first synthesis of N,N-disubstituted 5-aminothiophene-2-carboxaldehydes by Nucleophilic Aromatic Substitution of 5-bromothiophene-2-carboxaldehyde in water. This study shows selectivity between primary and secondary amines leading to