24377-95-5

Basic information

• Product Name: 3-CHLORO-4-METHYLBENZAMIDE
• Synonyms: 3-CHLORO-4-METHYLBENZAMIDE
• CAS NO: 24377-95-5
• Molecular Formula: C₈H₈ClNO
• Molecular Weight: 169.61
• Mol File: 24377-95-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 142-144°C
• Boiling Point: 262.7 °C at 760 mmHg
• Flash Point: 112.7 °C
• Appearance: /
• Density: 1.243 g/cm³
• Vapor Pressure: 0.0107mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: 3-CHLORO-4-METHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-METHYLBENZAMIDE(24377-95-5)
• EPA Substance Registry System: 3-CHLORO-4-METHYLBENZAMIDE(24377-95-5)

Safety Data

• Hazardous Substances Data: 24377-95-5(Hazardous Substances Data)

Usage

General Description

3-chloro-4-methylbenzamide is a chemical compound with the molecular formula C8H8ClNO. It is a pale yellow solid that is commonly used in various industrial and research applications. 3-chloro-4-methylbenzamide is structurally similar to benzamide, with a chlorine atom and a methyl group attached to the benzene ring. 3-chloro-4-methylbenzamide has the potential to be a useful building block for the synthesis of various pharmaceuticals and agrochemicals. It is also used as a reagent in organic chemistry and as an intermediate in the production of dyes and pigments. Overall, this compound has a wide range of applications and is an important chemical in various industries.

InChI:InChI=1/C8H8ClNO/c1-5-2-3-6(8(10)11)4-7(5)9/h2-4H,1H3,(H2,10,11)

Upstream product

• 7664-93-9 sulfuric acid 
• 21423-81-4 3-chloro-4-methylbenzonitrile 
• 39652-32-9 (3-chloro-4-methylphenyl) methanol 
• 95-74-9 3-chloro-p-toluidine 

Downstream Products

• 3932-97-6 4-bromomethyl-3-chloro-benzamide 

Relevant articles and documents

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Atomically Dispersed Ru on Manganese Oxide Catalyst Boosts Oxidative Cyanation

There is a strong incentive for environmentally benign and sustainable production of organic nitriles to avoid the use of toxic cyanides. Here we report that manganese oxide nanorod-supported single-site Ru catalysts are active, selective, and stable for oxidative cyanation of various alcohols to give the corresponding nitriles with molecular oxygen and ammonia as the reactants. The very low amount of Ru (0.1 wt %) with atomic dispersion boosts the catalytic performance of manganese oxides. Experimental and theoretical results show how the Ru sites enhance the ammonia resistance of the catalyst, bolstering its performance in alcohol dehydrogenation and oxygen activation, the key steps in the oxidative cyanation. This investigation demonstrates the high efficiency of a single-site Ru catalyst for nitrile production.

One-pot synthesis of symmetrical 1,3-diarylureas or substituted benzamides directly from benzylic primary alcohols and effective oxidation of secondary alcohols to ketones using phenyliodine diacetate in combination with sodium azide

Benzylic primary alcohols can be directly converted into symmetrical 1,3-diarylureas or substituted benzamides via an one-pot oxidative reaction using the combined reagent of phenyliodine diacetate and sodium azide. This new reaction constitutes a step-economical way to prepare symmetric 1,3-diarylureas or substituted benzamides depending upon the substituents on the phenyl rings of starting alcohols. The sodium acetate generated in situ from the ligand exchange between phenyliodine diacetate and sodium azide plays the pivotal role in the formation of 1,3-diarylureas. In addition, it is also found that various secondary alcohols can be readily oxidized to their corresponding ketones in excellent yields using the same reagent system of phenyliodine diacetate and sodium azide. Generally, secondary alcohols are preferentially oxidized to the corresponding ketones in the presence of primary ones with the limited amounts of phenyliodine diacetate and sodium azide.