2438-46-2

Basic information

• Product Name: (E)-N-hydroxy-1-[1-(2-{4-[(E)-(hydroxyimino)methyl]piperidin-1-yl}ethyl)-1,2-dihydropyridin-4-yl]methanimine
• CAS NO: 2438-46-2
• Molecular Formula: C₁₄H₂₂N₄O₂
• Molecular Weight: 278.3501
• Mol File: 2438-46-2.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 480.604°C at 760 mmHg
• Flash Point: 244.461°C
• Density: 1.229g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.602
• CAS DataBase Reference: (E)-N-hydroxy-1-[1-(2-{4-[(E)-(hydroxyimino)methyl]piperidin-1-yl}ethyl)-1,2-dihydropyridin-4-yl]methanimine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-hydroxy-1-[1-(2-{4-[(E)-(hydroxyimino)methyl]piperidin-1-yl}ethyl)-1,2-dihydropyridin-4-yl]methanimine(2438-46-2)
• EPA Substance Registry System: (E)-N-hydroxy-1-[1-(2-{4-[(E)-(hydroxyimino)methyl]piperidin-1-yl}ethyl)-1,2-dihydropyridin-4-yl]methanimine(2438-46-2)

Safety Data

• Hazardous Substances Data: 2438-46-2(Hazardous Substances Data)

Usage

General Description

(E)-N-hydroxy-1-[1-(2-{4-[(E)-(hydroxyimino)methyl]piperidin-1-yl}ethyl)-1,2-dihydropyridin-4-yl]methanimine, also known as HET0016, is a chemical compound that belongs to the class of hydroxamic acids. It is a potent and selective inhibitor of the enzyme 20-HETE synthase and has been studied for its potential therapeutic applications in various cardiovascular and inflammatory conditions. HET0016 has been shown to exhibit antihypertensive, anti-inflammatory, and anti-angiogenic effects in preclinical studies. Its ability to modulate the synthesis of 20-HETE, a vasoconstrictor and pro-inflammatory eicosanoid, makes it a promising candidate for the development of novel therapeutics for conditions such as hypertension, stroke, and inflammation. Further research is needed to fully understand its pharmacological properties and potential clinical applications.

Upstream product

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