24384-86-9Relevant academic research and scientific papers
A method for preparing N-alkylated kanosamines from diacetone D-glucose
Cannone, Zachary P.,Peczuh, Mark W.
supporting information, p. 1830 - 1833 (2019/06/19)
The aminoglycoside (AG) antibiotics have seen a resurgence in their clinical use given the increase in multi drug resistant bacterial infections. Campaigns to generate novel analogs show promise that structural modification can lead to compounds with improved pharmacological properties. The results described herein include a new method to synthesize mono-, di-, and mixed N-alkylated kanosamine sugars and their elaboration into novel glycosides that inhibit bacterial protein synthesis in vitro.
Enantiopure 2-Thioxotetrahydro-1,3-O,N-heterocycles from Carbohydrates. 3. Enantiopure C-4 Chiral Oxazine- and Oxazolidine-2-thiones from 3-Deoxy-3-isothiocyanato Sugars
Fernandez, Jose M. Garcia,Mellet, Carmen Ortiz,Blanco, Jose L. Jimenez,Fuentes, Jose
, p. 5565 - 5572 (2007/10/02)
The synthesis of 3-deoxy-3-isothiocyanato derivatives of D-glucose, D-allose, and D-galactose is reported.The intramolecular cyclization of partially or fully unprotected 3-deoxy-3-isothiocyanates has been found to proceed with total stereocontrol, the ou
