243841-08-9 Usage
Uses
Used in Pharmaceutical Industry:
TERT-BUTYL 3-(1H-INDOL-1-YL)PROPYLCARBAMATE is used as a building block for the preparation of indolocarbazoles, which are known as Chk1 inhibitors. These inhibitors play a significant role in the development of anticancer drugs, as they target the checkpoint kinase 1 (Chk1) enzyme, which is involved in the regulation of cell cycle progression and DNA damage response. By inhibiting Chk1, these compounds can potentially enhance the effectiveness of DNA-damaging anticancer agents and improve the treatment of various types of cancer.
Used in the Synthesis of GF109203x Analogs:
TERT-BUTYL 3-(1H-INDOL-1-YL)PROPYLCARBAMATE is also utilized in the synthesis of indolocarbazoles related to GF109203x, a potent and selective inhibitor of protein kinase C (PKC). PKC is a family of serine/threonine kinases that play a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis. The development of GF109203x analogs using TERT-BUTYL 3-(1H-INDOL-1-YL)PROPYLCARBAMATE as a building block can lead to the discovery of new and more effective PKC inhibitors, which may have potential applications in the treatment of various diseases, including cancer, inflammatory disorders, and neurological conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 243841-08-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,3,8,4 and 1 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 243841-08:
(8*2)+(7*4)+(6*3)+(5*8)+(4*4)+(3*1)+(2*0)+(1*8)=129
129 % 10 = 9
So 243841-08-9 is a valid CAS Registry Number.
243841-08-9Relevant academic research and scientific papers
Roy, Sudipta,Eastman, Alan,Gribble, Gordon W.
, p. 3228 - 3234 (2006)
From a structure-activity relationship perspective, the new indolocarbazoles 11 and 12 have been synthesized and evaluated biologically as novel Chk1 inhibitors. Compounds 11 and 12 were synthesized in high yield from indole via bisindolylmaleimides 18 and 24. The Royal Society of Chemistry 2006.
