243844-36-2

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 118-92-3 anthranilic acid 
• 164226-32-8 2-(tert-butyloxycarbonyl)aminobenzyl alcohol 
• 5344-90-1 2-Aminobenzyl alcohol 

Downstream Products

• 138343-89-2 tert-butyl 2-phenyl-1H-indole-1-carboxylate 
• 157427-60-6 2-(4-cyanophenyl)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester 
• 1189116-95-7 tert-butyl 2-(3-methoxyphenyl)-1H-indole-1-carboxylate 
• 55968-16-6 2-(2-thienyl)indole 
• 129822-52-2 [2-(2-Oxo-2-phenyl-ethyl)-phenyl]-carbamic acid tert-butyl ester 
• 85115-10-2 3-amino-1,2,3,4-tetrahydroquinolin-2-one 

Relevant academic research and scientific papers

N-Heterocyclic Carbene-Catalyzed Synthesis of 2-Aryl Indoles

Transition metal-free catalytic methods for access to 2-arylindole compounds.

N-heterocyclic-carbene-catalyzed synthesis of 2-aryl indoles

A convergent and efficient transition-metal-free catalytic synthesis of 2-aryl-indoles has been developed. The interception of a highly reactive and transient aza-ortho-quinone methide by an acyl anion equivalent generated through N-hetereocyclic carbene catalysis is central to this successful strategy. High yields and a wide scope as well as the streamlined synthesis of a kinase inhibitor are reported. Umpolung: N-heterocyclic carbene catalysis is used for the convergent and efficient transition-metal-free synthesis of 2-aryl-indoles. The interception of a highly reactive and transient aza-ortho-quinone methide by an acyl anion equivalent is central to this successful strategy. The reaction exhibits high yields and a wide scope, and it has been applied to a streamlined synthesis of a kinase inhibitor.