24393-13-3

Basic information

• Product Name: Phenol, 3-(1,3-dioxan-2-yl)-
• CAS NO: 24393-13-3
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Mol File: 24393-13-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Phenol, 3-(1,3-dioxan-2-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 3-(1,3-dioxan-2-yl)-(24393-13-3)
• EPA Substance Registry System: Phenol, 3-(1,3-dioxan-2-yl)-(24393-13-3)

Safety Data

• Hazardous Substances Data: 24393-13-3(Hazardous Substances Data)

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 34231-78-2 3-formylphenyl acetate 
• 504-63-2 trimethyleneglycol 

Downstream Products

• 81245-37-6 2-<2-iodo-3-(methoxymethoxy)phenyl>-1,3-dioxane 
• 81245-36-5 2-<6-iodo-3-(methoxymethoxy)phenyl>-1,3-dioxane 
• 1186601-41-1 2-(3-(1,3-dioxan-2-yl)phenoxy)-5-methoxybenzaldehyde 

Relevant articles and documents

Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors

Mycobacterium tuberculosis thymidylate kinase (MtTMPK) has emerged as an attractive target for rational drug design. We recently investigated new families of non-nucleoside MtTMPK inhibitors in an effort to diversify MtTMPK inhibitor chemical space. We here report a new series of MtTMPK inhibitors by combining the Topliss scheme with rational drug design approaches, fueled by two co-crystal structures of MtTMPK in complex with developed inhibitors. These efforts furnished the most potent MtTMPK inhibitors in our assay, with two analogues displaying low micromolar MIC values against H37Rv Mtb. Prepared inhibitors address new sub-sites in the MtTMPK nucleotide binding pocket, thereby offering new insights into its druggability. We studied the role of efflux pumps as well as the impact of cell wall permeabilizers for selected compounds to potentially provide an explanation for the lack of correlation between potent enzyme inhibition and whole-cell activity.

An efficient procedure for the preparation of cyclic ketals and thioketals catalyzed by zirconium sulfophenyl phosphonate

A convenient method for the preparation of cyclic ketals and thioketals using zirconium sulfophenyl phosphonate as catalyst is described.

Synthese d'acetals cycliques dans des conditions douces; Applications a l'acetalisation du chloramphenicol

Acetalization of 1-2 and 1-3 diols, even as sterically crowded as chloramphenicol, by carbonyl derivatives with substituents of various sizes has been performed at room temperature under mild conditions, by using heterogeneous catalysis (sulfonated polystyrene) in the presence of molecular sieves.Several new acetals of chloramphenicol have thus been obtained in good yields, isolated and characterized.