24393-38-2

Upstream product

• 141-97-9 ethyl acetoacetate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 1022149-96-7 C₁₈H₂₁N₃O₄ 
• 56245-20-6 ethyl 2-(3,4-dimethoxybenzyl)-3-oxobutanoate 
• 56245-24-0 2-amino-5-(3,4-dimethoxy-benzyl)-6-methyl-3H-pyrimidin-4-one 
• 748157-79-1 1-(3,4-dimethoxy-phenyl)-3-hydroxy-6-methoxy-5,8-dioxo-4,4a,5,8-tetrahydro-naphthalene-2-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Design and synthesis of 4-alkyl-2-amino(acetamino)-6-aryl-1,3-thiazine derivatives as influenza neuraminidase inhibitors

With a convenient and economical method, two series of 1,3-thiazine derivatives 1 and 2 were synthesized, and their neuraminidase (NA) inhibitory activities were evaluated. The pharmacological results showed that most of the compounds have potent NA inhibitory activity. Especially, 1g exhibited the best activity against influenza virus A (H1N1) NA (IC50 = 29.06 μg/mL), and its crystal structure was determined by single-crystal X-ray diffraction. The preliminary biological assay indicated that 1,3-thiazine could be used as a core structure to design novel influenza NA inhibitors. Two series of novel 1,3-thiazine analogs were synthesized and their neuraminidase (NA) inhibitory activities were evaluated. Most of the compounds have potent NA inhibitory activity. Compound 1g exhibited the best activity against influenza virus A (H1N1) NA with an IC50 of 29.06 μg/mL, and its crystal structure was determined by single-crystal X-ray diffraction.

A facile synthesis of trisubstituted alkenes from β-diketones and aldehydes with AlCl3 as catalyst

Preparation of trisubstituted alkenes from low-activity β-diketones and aldehydes with aluminum chloride as catalyst has been studied. The frequently used catalyst AlCl3 is used for the first time to promote this condensation. The procedure is a convenient, low toxicity, and highly efficient method for industrial synthesis of trisubstituted alkenes in high yield. Springer Science+Business Media B.V. 2011.

Treatment with dialkoxy pyridopyrimidine compounds

This application is directed to treatment of psoriasis with a pyrido pyrimidine compound such as 2,4-diamino-6-(3,4-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine.