1022149-96-7Relevant academic research and scientific papers
Synthesis of 6-amino-1,4-dihydropyridines that prevent calcium overload and neuronal death
Leon, Rafael,de los Rios, Cristobal,Marco-Contelles, Jose,Lopez, Manuela G.,Garcia, Antonio G.,Villarroya, Mercedes
, p. 668 - 674 (2008)
The synthesis and pharmacology of 6-amino-1,4-dihydropyridines, such as ethyl 6-amino-4-aryl-5-cyano-1,4-dihydro-2-methyl-3-pyridinecarboxylic acids (3-16) and 2-amino-4-aryl-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinenitriles (17-21) are described. Compounds 18 and 21, at the concentration of 0.3 μM, proved to be the best blockers of the [Ca2+] overload induced by depolarization with high [K+] of SH-SY5Y neuroblastoma cells, with values of 63.8% and 50.4%, respectively. Most of the compounds induced a remarkable neuroprotective effect against toxicity caused by high [K+]-elicited [Ca2+] overload, and against H2O2-generated free radicals, in SH-SY5Y cells.
Organic base grafted on magnetic nanoparticles as a recoverable catalyst for the green synthesis of hydropyridine rings
Bodaghifard, Mohammad Ali
, p. 483 - 492 (2020)
Synthesis of 4-aminiquinaldine grafted on silica-coated nano-Fe3O4 particles (MNPs-AQ) and their performance as a retrievable heterogeneous basic catalyst are disclosed. The catalytic performance of this novel material was studied fo
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease
Marco-Contelles, José,León, Rafael,De Los Ríos, Cristóbal,Samadi, Abdelouahid,Bartolini, Manuela,Andrisano, Vincenza,Huertas, Oscar,Barril, Xavier,Luque, F. Javier,Rodríguez-Franco, María I.,López, Beatriz,López, Manuela G.,García, Antonio G.,Carreiras, María Do Carmo,Villarroya, Mercedes
supporting information; experimental part, p. 2724 - 2732 (2010/02/28)
Tacripyrines (1-14) have been designed by combining an AChE inhibitor (tacrine) with a calcium antagonist such as nimodipine and are targeted to develop a multitarget therapeutic strategy to confront AD. Tacripyrines are selective and potent AChE inhibito
