243983-70-2

Basic information

• Product Name: 1-Cyclohexene-1-carboxylic acid, 6-[[(2-chloro-4-fluorophenyl)aMino]sulfonyl]-, ethyl ester
• Synonyms: 1-Cyclohexene-1-carboxylic acid, 6-[[(2-chloro-4-fluorophenyl)aMino]sulfonyl]-, ethyl ester;ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfaMoyl)cyclohex-1-enecarboxylate;Ethyl 6-[N-(4-Chloro-2-fluorophenyl)sulfaMoyl]cyclohex-1-ene-1-carboxylate;LEEIJTHMHDMWLJ-UHFFFAOYSA-N
• CAS NO: 243983-70-2
• Molecular Formula: C₁₅H₁₇ClFNO₄S
• Molecular Weight: 361.8161832
• Mol File: 243983-70-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Cyclohexene-1-carboxylic acid, 6-[[(2-chloro-4-fluorophenyl)aMino]sulfonyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclohexene-1-carboxylic acid, 6-[[(2-chloro-4-fluorophenyl)aMino]sulfonyl]-, ethyl ester(243983-70-2)
• EPA Substance Registry System: 1-Cyclohexene-1-carboxylic acid, 6-[[(2-chloro-4-fluorophenyl)aMino]sulfonyl]-, ethyl ester(243983-70-2)

Safety Data

• Hazardous Substances Data: 243983-70-2(Hazardous Substances Data)

Usage

General Description

1-Cyclohexene-1-carboxylic acid, 6-[[(2-chloro-4-fluorophenyl)aMino]sulfonyl]-, ethyl ester is a chemical compound with the molecular formula C18H19ClFNO4S. It is a member of the ethyl ester class of compounds and contains a cyclohexene ring, a carboxylic acid group, and a sulfonamide group. This chemical is commonly used in pharmaceutical research as a potential drug target, particularly in the field of antineoplastic and anti-inflammatory medications. Its unique structure and sulfur-containing functional group make it a valuable building block for the synthesis of novel pharmaceutical compounds with potential therapeutic applications. Additionally, its chloro and fluorophenyl substituents make it a promising candidate for further investigation and optimization in drug design and development.

Upstream product

• 2106-02-7 2-chloro-4-fluoroaniline 
• 243984-26-1 ethyl 2-(chlorosulfonyl)cyclohex-1-ene-1-carboxylate 
• 243984-25-0 2-(ethoxycarbonyl)cyclohex-1-ene-1-sulfonic acid 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 54928-91-5 ethyl 2-mercaptocyclohex-1-ene-1-carboxylate 

Downstream Products

• 1000872-35-4 ethyl 6-[((2-chloro-4-fluorophenyl){3,5-dimethyl-4-[(N-methylglycyl)oxy]benzyl}amino)sulfonyl]cyclohex-1-ene-1-carboxylate hydrochloride 
• 1000872-39-8 5-((2-chloro-4-fluorophenyl){[2-(ethoxycarbonyl)cyclohex-2-en-1-yl]sulfonyl}amino)-5-oxopentanoic acid 
• 1000872-33-2 N-{[((2-chloro-4-fluorophenyl){[2-(ethoxycarbonyl)cyclohex-2-en-1-yl]sulfonyl}amino)methoxy]carbonyl}-D-leucine 
• 1000872-19-4 (2S)-2-({[((2-chloro-4-fluorophenyl){[2-(ethoxycarbonyl)cyclohex-2-en-1-yl]sulfonyl}amino)methoxy]carbonyl}oxy)propanoic acid 
• 1000872-29-6 sodium (1-{[((2-chloro-4-fluorophenyl){[2-(ethoxycarbonyl)cyclohex-2-en-1-yl]sulfonyl}amino)methoxy]carbonyl}piperidin-4-yl)acetate 
• 1000872-17-2 sodium 4-({[((2-chloro-4-fluorophenyl){[2-(ethoxycarbonyl)cyclohex-2-en-1-yl]sulfonyl}amino)methoxy]carbonyl}oxy)butanoate 
• 1000872-28-5 (1-{[((2-chloro-4-fluorophenyl){[2-(ethoxycarbonyl)cyclohex-2-en-1-yl]sulfonyl}amino)methoxy]carbonyl}piperidin-4-yl)acetic acid 
• 1000872-16-1 4-({[((2-chloro-4-fluorophenyl){[2-(ethoxycarbonyl)cyclohex-2-en-1-yl]sulfonyl}amino)methoxy]carbonyl}oxy)butanoic acid 
• 1000872-31-0 N-{[((2-chloro-4-fluorophenyl){[2-(ethoxycarbonyl)cyclohex-2-en-1-yl]sulfonyl}amino)methoxy]carbonyl}glycine 
• 1000872-43-4 4-((2-chloro-4-fluorophenyl){[2-(ethoxycarbonyl)cyclohex-2-en-1-yl]sulfonyl}amino)-4-oxobutanoic acid 
• 1000872-53-6 ethyl 6-{[(2-chloro-4-fluorophenyl)(glycoloyl)amino]sulfonyl}cyclohex-1-ene-1-carboxylate 
• 1000872-56-9 ethyl 6-{[[4-(benzyloxy)-4-oxobutanoyl](2-chloro-4-fluorophenyl)amino]sulfonyl}cyclohex-1-ene-1-carboxylate 
• 1000872-41-2 ethyl 6-({(2-chloro-4-fluorophenyl)[4-oxo-4-(2,2,2-trichloroethoxy)butanoyl]amino}sulfonyl)cyclohex-1-ene-1-carboxylate 
• 1000872-38-7 ethyl 6-({(2-chloro-4-fluorophenyl)[5-oxo-5-(2,2,2-trichloroethoxy)pentanoyl]amino}sulfonyl)cyclohex-1-ene-1-carboxylate 

Relevant articles and documents

Design and Catalyzed Activation of Tak-242 Prodrugs for Localized Inhibition of TLR4-Induced Inflammation

Tak-242 (resatorvid), a Toll-like Receptor 4 (TLR4) inhibitor, has been identified as a potent suppressor of innate inflammation. As a strategy to target Tak-242 to select tissue, four TLR4-inactive prodrugs were synthesized for activation via two different release mechanisms. Two nitrobenzyl Tak-242 prodrugs released the parent drug upon exposure to the exogenous enzyme nitroreductase, while the two propargyl prodrugs were converted to Tak-242 in the presence of Pd0.

SUBSTITUTED CYCLOHEXENES

Disclosed herein are substituted cyclohexene TLR4 signaling pathway modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.

Cycloalkene derivatives, process for producing the same, and use

The present invention provides a compound represented by the formula: wherein R represents an aliphatic hydrocarbon group optionally having substituents, an aromatic hydrocarbon group optionally having substituents, a heterocyclic group optionally having