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ethyl 2-(chlorosulfonyl)cyclohex-1-enecarboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 243984-26-1 Structure
  • Basic information

    1. Product Name: ethyl 2-(chlorosulfonyl)cyclohex-1-enecarboxylate
    2. Synonyms: ethyl 2-(chlorosulfonyl)cyclohex-1-enecarboxylate
    3. CAS NO:243984-26-1
    4. Molecular Formula:
    5. Molecular Weight: 252.719
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 243984-26-1.mol
  • Chemical Properties

    1. Melting Point: 32-33 °C(Solv: ethyl acetate (141-78-6))
    2. Boiling Point: 347.6±42.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: 1.35±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: ethyl 2-(chlorosulfonyl)cyclohex-1-enecarboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: ethyl 2-(chlorosulfonyl)cyclohex-1-enecarboxylate(243984-26-1)
    11. EPA Substance Registry System: ethyl 2-(chlorosulfonyl)cyclohex-1-enecarboxylate(243984-26-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 243984-26-1(Hazardous Substances Data)

243984-26-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 243984-26-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,3,9,8 and 4 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 243984-26:
(8*2)+(7*4)+(6*3)+(5*9)+(4*8)+(3*4)+(2*2)+(1*6)=161
161 % 10 = 1
So 243984-26-1 is a valid CAS Registry Number.

243984-26-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl 2-(chlorosulfonyl)-1-cyclohexene-1-carboxylate

1.2 Other means of identification

Product number -
Other names ethyl 2-(chlorosulfonyl)cyclohex-1-ene-1-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:243984-26-1 SDS

243984-26-1Relevant articles and documents

Preparation method 2 - (chlorosulfonyl) cyclohexane -1 - allyl formate derivative

-

, (2021/11/14)

The invention relates to a preparation method of 2 - (chlorosulfonyl) cyclohexane -1 - allyl formate derivative, which comprises the following steps: 1) dissolving the compound of formula III in an organic solvent; and reacting the compound of formula IV

DIRECTED CONJUGATION TECHNOLOGIES

-

, (2021/05/29)

Among other things, the present disclosure provides technologies for site-directed conjugation of various moieties of interest to target agents. In some embodiments, the present disclosure utilizes target binding moieties to provide high conjugation efficiency and selectivity. In some embodiments, provided technologies are useful for preparing antibody conjugates.

Synthesis and rational design of anti-inflammatory compounds: N-phenyl-cyclohexenyl sulfonamide derivatives

Lloret, Gustavo R.,Neto, Alvaro Cunha,Rittner, Roberto,Bitencourt, Michelle,Freitas, Matheus P.,Aquino, Nilton S.

experimental part, p. 1188 - 1192 (2010/07/13)

The synthesis of (±)-ethyl 6-[N-(2-chloro-4-fluorophenyl)sulfamoyl] cyclohex-1-ene-1-carboxylate (5n) has been reproduced from a method previously described and served as the background for the preparation of a nitro derivative, potentially useful as an a

SUBSTITUTED CYCLOHEXENES

-

, (2009/02/11)

Disclosed herein are substituted cyclohexene TLR4 signaling pathway modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.

SUBSTITUTED CYCLOHEXENES

-

Page/Page column 65, (2009/03/07)

Disclosed herein are deuterated derivatives of TAK-242 of Formula (I) which are modulators of TLR4 signalling pathway, pharmaceutical compositions thereof and methods of use thereof. Formula (I)

Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: Synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate

Yamada, Masami,Ichikawa, Takashi,Ii, Masayuki,Sunamoto, Mie,Itoh, Katsumi,Tamura, Norikazu,Kitazaki, Tomoyuki

, p. 7457 - 7467 (2007/10/03)

To develop a new therapeutic agent for sepsis, screening of the Takeda chemical library was carried out using mouse macrophages stimulated with lipopolysaccharide (LPS) to identify a new class of small-molecule inhibitors of inflammatory mediator production. The lead compound 5a was discovered, from which a series of novel cyclohexene derivatives I bearing a sulfamoyl and ester group were designed, synthesized and tested for their inhibitory activity against nitric oxide (NO) production. Derivatives I were synthesized by the coupling of sulfonyl chlorides and anilines with concomitant double bond migration in the presence of triethylamine, and phenyl ring substitution and modification of the ester and cyclohexene moieties were carried out. Among the compounds synthesized, ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]- cyclohex-1-ene-1-carboxylate [(R)-(+)-5n, TAK-242] was found to exhibit the most potent suppressive activity for the production of not only NO but also inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) induced by LPS-stimulated mouse macrophages with IC 50 values of 1.8, 1.9 and 1.3 nM, respectively. It shows marked beneficial effects in vivo also. Intravenous administration of (R)-(+)-5n at doses of 0.1 mg/kg or more suppressed the production of NO and various cytokines [TNF-α, IL-6 and IL-1β] in the mouse endotoxin shock model. Furthermore, it protected mice from death dose-dependently and all mice survived at a dose of 3 mg/kg. The minimum effective dose to protect mice from lethality in this model was 0.3 mg/kg, which was consistent with those for inhibitory effects on the production of NO and cytokines. Compound CR)-(+)-5n is currently undergoing clinical trials for the treatment of sepsis.

Cycloalkene derivatives, process for producing the same, and use

-

, (2008/06/13)

The present invention provides a compound represented by the formula: wherein R represents an aliphatic hydrocarbon group optionally having substituents, an aromatic hydrocarbon group optionally having substituents, a heterocyclic group optionally having

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