244-69-9

Basic information

• Product Name: gamma-carboline
• Synonyms: gamma-carboline;g-Carboline;5H-pyrido[4,3-b]indole;pyrido[4,3-b]indole;3-Azacarbazole;NSC 160470;3-PI;5H-Pyrido[4,3-b]indole
• CAS NO: 244-69-9
• Molecular Formula: C₁₁H₈N₂
• Molecular Weight: 168.198
• Mol File: 244-69-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 230-231℃ (methanol water )
• Boiling Point: 391.3°Cat760mmHg
• Flash Point: 182.1°C
• Appearance: /
• Density: 1.352
• Vapor Pressure: 5.62E-06mmHg at 25°C
• Refractive Index: 1.664 (589.3 nm 25℃)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 15.08±0.30(Predicted)
• Merck: 14,1805
• CAS DataBase Reference: gamma-carboline(CAS DataBase Reference)
• NIST Chemistry Reference: gamma-carboline(244-69-9)
• EPA Substance Registry System: gamma-carboline(244-69-9)

Safety Data

• Hazardous Substances Data: 244-69-9(Hazardous Substances Data)

Usage

Purification Methods

Crystallise it from water or EtOAc. [Robinson & Thornley J Chem Soc 12S 2169 1924, Dalton et al. Aust J Chem 22 185 1969, Staab & Wendel Org Synth 48 44 1968, Beilstein 23 II 223, 23 III/IV 1572.]

InChI:InChI=1/C11H8N2/c1-2-4-10-8(3-1)9-7-12-6-5-11(9)13-10/h1-7,13H

Upstream product

• 109073-14-5 1-(3-nitro-4-pyridyl)-benzo-1,2,3-triazole 
• 856849-78-0 3-(2-azidophenyl)pyridine 
• 91-17-8 decalin 
• 622-88-8 4-bromophenylhydrazine hydrochloride 
• 27246-81-7 3-bromophenylhydrazine hydrochloride 

Downstream Products

• 1309378-44-6 5-(2-bromophenyl)-5H-pyrido[4,3-b]indole 
• 1309378-36-6 methyl 2-pyrido[4,3-b]indol-5-ylbenzoate 
• 1309378-41-3 8,8-Dimethyl-6,10-bis[1,1';3',1]terphenyl-5'-yl-8H-3,12b-diazabenzo[a]aceanthrylene 
• 1303503-83-4 8-[9,10-di(naphthalen-2-yl)-anthracen-2-yl)-1,5-diphenyl-5H-pyrido[4,3-b]indole 
• 1303503-73-2 8-[9,10-di(naphthalen-2-yl)-anthracen-2-yl]-5-phenyl-5H-pyrido[4,3-b]indole 
• 1303503-72-1 8-(9,10-diphenylanthracen-2-yl)-5-phenyl-5H-pyrido[4,3-b]indole 
• 1303503-70-9 8-bromo-5-phenyl-5H-pyrido[4,3-b]indole 
• 1303503-71-0 8-[10-(naphthalen-2-yl)-anthracen-9-yl]-5-phenyl-5H-pyrido[4,3-b]indole 
• 1303503-69-6 5-phenyl-5H-pyrido[4,3-b]indole 

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A comparative study performed in mice investigating the action of DF302, a novel fluoride-containing gamma-carboline derivative, in comparison to the structurally similar neuroprotective drug dimebon. Drug effects on learning and memory, emotionality, hippocampal neurogenesis and mitochondrial f...detailed

Relevant articles and documents

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FLASH-VACUUM PYROLYSIS OF NITROARYLBENZOTRIAZOLES. A TANDEM MASS SPECTROMETRY STUDY

Tandem mass spectrometry (MS/MS) has been applied to investigate the behaviour of 1-(2-nitrophenyl)benzotriazole upon flash-vacuum pyrolysis (FVP) conditions.Above 500 deg C, is pyrolyzed to give a mixture of 1-nitrocarbazole , 1-hydroxycarbazole and carbazole .Under similar conditions, 2-(2-nitrophenyl)benzotriazole appears to be more stable; it is however partially isomerized into 8 at high temperatures.Aza analogs of 8, like 1-(2-nitro-4-pyridyl)benzotriazole also loose nitrogen above 500 deg C to give a mixture of 1-nitro-3-azacarbazole , 1-hydroxy-3-azacarbazole and 3-azacarbazole .