244-92-8

Upstream product

• 31522-88-0 4-hydrazino-benzo[4,5]thieno[2,3-d]pyridazine 
• 37412-20-7 benzo[4,5]thieno[2,3-d]pyridazine-4-carboxylic acid 
• 37412-25-2 benzo[4,5]thieno[2,3-d]pyridazine-1-carboxylic acid 
• 24049-98-7 1-hydrazino-benzo[4,5]thieno[2,3-d]pyridazine 
• 30446-99-2 2-methylbenzo[b]thiophene-3-carboxaldehyde 
• 37412-10-5 N,N-diethyl-2-(3-formyl-benzo[b]thiophen-2-yl)-2-oxo-acetamide 
• 5381-20-4 benzothiophene-3-carboxaldehyde 
• 68-12-2 N,N-dimethyl-formamide 
• 37412-24-1 2-benzoyl-1,2-dihydro-benzo[4,5]thieno[2,3-d]pyridazine-1-carbonitrile 
• 37412-19-4 benzo[4,5]thieno[2,3-d]pyridazine-4-carboxylic acid diethylamide 
• 541506-43-8 diethyl 2-{[2-(bromomethyl)benzo[b]thiophen-3-yl]methylene}malonate 
• 541506-42-7 diethyl 2-[(2-methylbenzo[b]thiophen-3-yl)methylene]malonate 
• 541506-51-8 3,4-dihydrobenzo[4,5]thieno[2,3-d]pyridazine 
• 7137-33-9 benzo[b]thiophene-2,3-dicarbaldehyde 

Downstream Products

• 37412-24-1 2-benzoyl-1,2-dihydro-benzo[4,5]thieno[2,3-d]pyridazine-1-carbonitrile 

Relevant academic research and scientific papers

One-pot synthesis of phthalazines and pyridazino-aromatics: A novel strategy for substituted naphthalenes

A new one-pot strategy for the synthesis of phthalazines and pyridazino-aromatics starting from aromatic aldehydes has been developed. A variety of substituents ranging from electron withdrawing to donating is tolerated furnishing the desired 1,2-diazine in good to excellent yields. The products have been applied to the bidentate Lewis acid catalyzed inverse electron-demand Diels-Alder (IEDDA) reaction opening a novel two-step entry into substituted naphthalenes, such as Naproxen.

Synthesis and Diels-Alder reactions of the benzo[4,5]thieno [2,3-c]pyrrole ring system

The first synthesis of the parent compound of the benzo[4,5]thieno[2,3-c]pyrrole ring system and its derivatives, as well as their Diels-Alder reactions with DMAD and N-phenylmaleimide are reported. A new synthesis of the benzo[4,5]thieno[2,3-d]pyridazine ring system is also described.