30446-99-2

Usage

InChI:InChI=1/C10H8OS/c1-7-9(6-11)8-4-2-3-5-10(8)12-7/h2-6H,1H3

Upstream product

• 1195-14-8 2-Methylbenzothiophene 
• 4885-02-3 Dichloromethyl methyl ether 
• 95-15-8 Benzo[b]thiophene 

Downstream Products

• 768370-20-3 (2-methyl-1,3-dioxo-2,3,3a,4,10,10a-hexahydro-1H-9-thia-2-aza-cyclopenta[b]fluoren-4-yl)-carbamic acid benzyl ester 
• 1569077-80-0 C₂₁H₂₁N₃O₄S 
• 541506-49-4 2-benzyl-2H-benzo[4,5]thieno[2,3-c]pyrrole 
• 244-92-8 benzo[4,5]thieno[2,3-d]pyridazine 

Relevant academic research and scientific papers

Synthesis of Chiral Polycyclic Tetrahydrocarbazoles by Enantioselective Aminocatalytic Double Activation of 2-Hydroxycinnamaldehydes with Dienals

An efficient aminocatalytic enantioselective double-activation strategy has been developed that combines several different aminocatalytic modes in a cascade process, such as iminium ion, vinylogous iminium ion, trienamine, and dienamine activations. By using this strategy, 2-hydroxycinnamaldehydes worked well with various dienals via [4 + 2] cycloaddition and the oxa-Michael reaction-initiated cascade, respectively, leading to chiral polycyclic tetrahydrocarbazole and chromane derivatives with excellent diastereo- and enantioselectivities.

Palladium-catalysed annulative allylic alkylation for the synthesis of benzannulated heteroarenes

A conceptually novel intramolecular allylic alkylation strategy is developed for the synthesis of carbazoles and dibenzothiophenes. In an unusual event, palladium catalyses the formation of π-allylpalladium complexes of the respective (2-methylindol-3-yl)allyl acetates and subsequently facilitates the benzannulation process. This journal is

Cyclopenta[b]annulation of Heteroarenes by Organocatalytic γ′[C(sp3)?H] Functionalization of Ynones

A new approach for the cyclopenta[b]annulation of heteroarenes through metal-free and directing-group-free γ′[C(sp3)?H] functionalization and intramolecular hydroalkylation of ynones has been developed. In an unprecedented event, nucleophilic addition of an organophosphine to the designed ynones triggers γ′[C(sp3)?H] functionalization, leading to the formation of heteroaryl-based ortho-quinodimethane (oQDM) intermediates that undergo carbocyclization to provide cyclopentannulated heteroarenes in good yields and excellent stereoselectivities. Deuterium-labeling experiments substantiated the proposed reaction mechanism as well as the speculated epimerization.

FAB I INHIBITORS

Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.

Dihydropyridines useful in the treatment of angina and stroke

This invention provides certain substituted dihydropyridines, their pharmaceutical formulations, and their use for causing vasodilation in mammals.