24401-38-5

Upstream product

• 24401-32-9 Dimethyl-(2-methyl-2,3-diphenylpropyliden)-ammoniumbromid 
• 6006-81-1 3-hydroxy-2-phenylpropene 
• 100-39-0 benzyl bromide 
• 98-83-9 isopropenylbenzene 
• 24397-66-8 trans-β-Dimethylamino-α-methylstyrol 
• 34713-70-7 2-Phenylpropanal 
• 13326-10-8 benzyl methyl carbonate 
• 100-51-6 benzyl alcohol 
• 591-50-4 iodobenzene 
• 3805-10-5 2,2-(dimethyl)-2-phenylacetaldehyde 

Relevant academic research and scientific papers

Palladium-catalyzed site-selective C(sp3)-H arylation of phenylacetaldehydes

We describe a Pd-catalyzed selective C-H arylation reaction of phenylacetaldehydes using l-valine as the transient directing group. This process showed a broad substrate scope and excellent selectivity in which a ligand-controlled functionalization of the

A 2 - methyl - 2, 3 - diaryl propionaldehyde derivative synthesis method

The invention discloses a 2 - methyl - 2, 3 - diaryl propionaldehyde derivative synthesis method, the method to the molecular formula is And of the compound as a raw material of the formula Aryl halides, amino acid, silver salt and two price arrowheads catalyst prepared under the effect of the molecule Of the 2 - methyl - 2, 3 - diaryl propionaldehyde derivatives; the invention through divalent palladium are the catalyst, through the amino acid as a transient guide base at the synthesis of 2 - methyl - 2, 3 - diaryl propionaldehyde derivatives, realizes the substrate range is not limited, the operation is simple, easily available raw material, the raw material cost, the role of the efficient reaction, at the same time use C - H arylation strategy effectively reduce the halide or to the use of halide, transient guide-based usage does make the reaction more simple, more economic.

A general Pd-catalyzed α- And γ-benzylation of aldehydes for the formation of quaternary centers

A palladium-catalyzed benzylation of α-branched aldehydes has been developed using benzyl methyl carbonates. The method gives access to congested quaternary centers in the vicinity of one of the most sensitive carbonyl functionalities and displays unprecedented generality with respect to both coupling partners. Evidence for the direct involvement of a Pd-η3-benzyl intermediate is provided. Extension of this strategy to the γ-benzylation of α,β-unsaturated aldehydes is further demonstrated.

The catalytic asymmetric α-benzylation of aldehydes

The first aminocatalyzed α-alkylation of α-branched aldehydes with benzyl bromides as alkylating agents has been developed. Using a sterically demanding proline derived catalyst, racemic α-branched aldehydes are reacted with alkylating agents in a DYKAT process to give the corresponding α-alkylated aldehydes with quaternary stereogenic centers in good yields and high enantioselectivities. A sterically demanding proline derivative promotes the first aminocatalyzed α-alkylation of α-branched aldehydes with benzyl bromides as alkylating agents. Racemic α-branched aldehydes react with alkylating agents in a DYKAT process to give the corresponding α-alkylated aldehydes with quaternary stereogenic centers in good yields and high enantioselectivities. Copyright

Rhodium promoted isomerisation of allylic alkoxides: A new method for enolate anion formation

Transition metal mediated isomerisation of allylic alkoxides is presented as a new method for enolate anion generation. The scope and limitations of enolate formation with the catalysts [Rh(dppe)(THF)2]+ClO4- and (Ph3P)3RhCl are explored and the synthetic potential of the methodology demonstrated in the stereoselective formation and reactions of certain ketone and aldehyde enolates.