244017-81-0

Basic information

• Product Name: 1H-Indazole, 1-(chloroacetyl)- (9CI)
• Synonyms: 1H-Indazole, 1-(chloroacetyl)- (9CI);2-Chloro-1-(1H-indazol-1-yl)ethanone
• CAS NO: 244017-81-0
• Molecular Formula: C9H7ClN2O
• Molecular Weight: 194.61768
• Product Categories: ACETYLHALIDE
• Mol File: 244017-81-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Indazole, 1-(chloroacetyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazole, 1-(chloroacetyl)- (9CI)(244017-81-0)
• EPA Substance Registry System: 1H-Indazole, 1-(chloroacetyl)- (9CI)(244017-81-0)

Safety Data

• Hazardous Substances Data: 244017-81-0(Hazardous Substances Data)

Usage

Class

1H-indazoles (compounds containing an indazole moiety, which consists of a pyrazole ring fused to a benzene ring)

Subclass

Halogenated indazoles

Functional group

Chloroacetyl group (an acetyl group bonded to a chlorine atom)

Potential applications

Pharmaceuticals, agrochemicals, and materials science (specific properties and uses may vary depending on exact application and formulation)

Upstream product

• 271-44-3 benzimidazole 
• 541-88-8 Chloroacetic anhydride 
• 21642-45-5 2-(2-chloro-acetylamino)-benzaldehyde-oxime 
• 3398-07-0 2-aminobenzaldehyde oxime 
• 79-04-9 chloroacetyl chloride 

Relevant articles and documents

Selective N1-Acylation of Indazoles with Acid Anhydrides Using an Electrochemical Approach

An electrochemical synthesis method for the selective N1-acylation of indazoles has been developed. This "anion pool" approach electrochemically reduces indazole molecules generating indazole anions and H2. Acid anhydrides are then introduced to the solution resulting in selective acylation of the N1-position of the indazoles. This procedure can also be applied to the acylation of benzimidazoles and indoles. The reaction can also be performed using a 9 V battery without loss of reaction efficiency.

Synthesis and biological evaluation of a new class of triazin-triazoles as potential inhibitors of human farnesyltransferase

A new synthesis of ethynyldimethoxytriazine 1, an important platform-compound for developing new chemical entities for anticancer research and for other biological applications, is described. Compound 1 was further reacted with azides 5a-i to provide triazin-triazoles 2a-i, which were tested on human farnesyltransferase and on the NCI-60 human tumor cell lines. Synthesis of other dimethoxytriazine derivatives 15 and 16, linked to a sp 2 or a sp 3 carbon atom were also studied. Graphical Abstract: [Figure not available: see fulltext.]