244055-83-2Relevant academic research and scientific papers
Enantioselective synthesis of the medium ring ethers, tetrahydrooxepin, oxocane and hexahydrooxonin, of ciguatoxin. Extensive ring-expansion and chemoenzymatic desymmetrization strategy
Oishi, Tohru,Maruyama, Megumi,Shoji, Mitsuru,Maeda, Kenji,Kumahara, Naomi,Tanaka, Shin-Ichiro,Hirama, Masahiro
, p. 7471 - 7498 (2007/10/03)
The extensive ring-expansion strategy for the synthesis of tetrahydrooxepin, oxocane, and hexahydrooxonin, which correspond to the D(E), I and F rings of ciguatoxin (CTX1B, 1). respectively, has been established. Chemoenzymatic acylation of the meso alcoh
