244092-65-7Relevant academic research and scientific papers
Room-temperature highly diastereoselective Zn-mediated allylation of chiral N-tert-butanesulfinyl imines: Remarkable reaction condition controlled stereoselectivity reversal
Sun, Xing-Wen,Xu, Ming-Hua,Lin, Guo-Qiang
, p. 4979 - 4982 (2006)
(Chemical Equation Presented) An efficient method for the highly diastereoselective synthesis of chiral homoallylic amines by Zn-mediated allylation of chiral N-tert-butanesulfinyl imines at room temperature was developed. By simply tuning the reaction co
Highly efficient asymmetric construction of quaternary carbon-containing homoallylic and homopropargylic amines
Guo, Tao,Song, Ran,Yuan, Bin-Hua,Chen, Xiao-Yang,Sun, Xing-Wen,Lin, Guo-Qiang
, p. 5402 - 5404 (2013/07/28)
A highly efficient method for the asymmetric synthesis of chiral quaternary carbon-containing homoallylic and homopropargylic amines under mild conditions was achieved with good yields and high diastereoselectivities.
Asymmetric synthesis of chiral amines by highly diastereoselective 1,2- additions of organometallic reagents to N-tert-butanesulfinyl imines
Cogan, Derek A.,Liu, Guangcheng,Ellman, Jonathan
, p. 8883 - 8904 (2007/10/03)
High yielding and highly diastereoselective methods for 1,2-additions of organometallic reagents to N-tert-butanesulfinyl aldimines (2) and N-tert- butanesulfinyl kerimines (3) are described. The additions of alkyl, aryl, alkenyl, and allyl carbanions to a diverse set of imines with different steric and electronic properties are demonstrated. Acidic methanolysis of the sulfinamide products (4 and 6) delivers highly enantioenriched α-branched and α,α-dibranched amines. Since a broad range of sulfinyl imines are easily accessible from aldehydes and ketones, a wide variety of enantioentriched amines may be prepared.
