244103-25-1

Upstream product

• 32316-92-0 naphthalene-2-boronic acid 
• 342777-09-7 (E)-3-(2-Bromomethyl-phenyl)-acryloyl chloride 
• 1663-39-4 tert-Butyl acrylate 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 939-26-4 2-bromomethylnaphthyl bromide 
• 342777-10-0 (E)-3-(2-Bromomethyl-phenyl)-acrylic acid 
• 60633-90-1 ethyl (E)-3-[2-(bromomethyl)phenyl]-2-propenoate 
• 24393-48-4 ethyl trans-2-methylcinnamate 
• 146793-49-9 methyl (E)-3-(2’-(bromomethyl)phenyl)acrylate 
• 70625-62-6 methyl (E)-3-(2-methylphenyl)-2-propenoate 
• 939-57-1 (E)-3-(2-methylphenyl)acrylic acid 
• 373380-73-5 3-(2-naphthalen-2-ylmethylphenyl)acrylic acid methyl ester 

Downstream Products

• 244101-02-8 (2E)-N-{[5-bromo-2-(methyloxy)phenyl]sulfonyl}-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide 

Relevant academic research and scientific papers

Three-component coupling of benzyne: Domino intermolecular carbopalladation

A new three-component coupling reaction of benzyne is described that uses two intermolecular carbopalladation reactions to produce 1,2-functionalized benzene derivatives. Copyright

Structure-activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry

Potent and selective EP3 receptor ligands were found by making a library using solid-support chemistry. These compounds can be obtained by a Suzuki coupling reaction of a solid-supported benzyl bromide using various boronic acids. The yields obtained for this reaction were in the range of 24-95% of arylmethyl cinnamic acid I after cleavage from the Wang resin,

Structure-activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor

Potent and selective antagonists of the human EP3 receptor have been identified. The structure-activity relationship of the chemical series was conducted and we found several analogues displaying sub-nanomolar Ki values at the EP3 receptor and micromolar activities at the EP1, EP2 and EP4 receptors. The effect of added human serum albumin (HSA) on the binding affinity at the EP3 receptor was also investigated.

Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment

Compounds of formula I: as well as pharmaceutically acceptable salts, hydrates and esters thereof, are disclosed. The compounds are useful for treating or preventing prostaglandin mediated diseases. Pharmaceutical compositions containing such compounds and methods of treatment are also included.