146793-49-9

Basic information

• Product Name: 2-Propenoic acid, 3-[2-(bromomethyl)phenyl]-, methyl ester, (2E)-
• CAS NO: 146793-49-9
• Molecular Formula: C11H11BrO2
• Molecular Weight: 255.111
• Mol File: 146793-49-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-[2-(bromomethyl)phenyl]-, methyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-[2-(bromomethyl)phenyl]-, methyl ester, (2E)-(146793-49-9)
• EPA Substance Registry System: 2-Propenoic acid, 3-[2-(bromomethyl)phenyl]-, methyl ester, (2E)-(146793-49-9)

Safety Data

• Hazardous Substances Data: 146793-49-9(Hazardous Substances Data)

Upstream product

• 939-57-1 (E)-3-(2-methylphenyl)acrylic acid 
• 70625-62-6 methyl (E)-3-(2-methylphenyl)-2-propenoate 

Downstream Products

• 373380-73-5 3-(2-naphthalen-2-ylmethylphenyl)acrylic acid methyl ester 
• 1311201-33-8 (E)-2-(2-(3-hydroxyprop-1-enyl)phenyl)acetic acid 
• 1311201-34-9 (E)-2-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)phenyl)acetic acid 
• 1311201-35-0 (E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 1311201-36-1 (E)-5-(2-(3-hydroxyprop-1-enyl)phenethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 244101-02-8 (2E)-N-{[5-bromo-2-(methyloxy)phenyl]sulfonyl}-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide 
• 244103-25-1 (E)-3-(2-((naphthalen-3-yl)methyl)phenyl)acrylic acid 
• 16261-32-8 methyl 2-(2-benzyl-1,2,3,4-tetrahydroisoquinolin-4-yl)acetate 
• 216572-78-0 3-(2-hydroxymethylphenyl)acrylic acid methyl ester 
• 52753-91-0 (E)-methyl 3-(2-formylphenyl)acrylate 
• 70625-51-3 2-Cyanmethyl-zimtsaeure-methylester 

Relevant articles and documents

Synthesis of Tetrahydroisoquinolines by Visible-Light-Mediated 6- exo -trig Cyclization of α-Aminoalkyl Radicals

Starting from the respective tertiary α-silylmethyl amines, the intramolecular cyclization of α-aminoalkyl radicals to Michael acceptors produced tetrahydroisoquinolines. The reaction conditions included the use of 5 molpercent of an iridium photoredox catalyst, dimethylformamide as the solvent, and equimolar amounts of water and cesium carbonate as the additives. 13 substrates were synthesized from ortho -alkylbenzaldehydes in a three-step procedure involving a carbonyl condensation, a radical bromination, and a substitution by a secondary α-silylmethyl amine. After optimization of the photocyclization, the reaction delivered tetrahydroisoquinolines in moderate to high yields (41-83percent). A facial diastereoselectivity (dr ? 80:20) was observed with chiral substrates and a crystal structure provided evidence for the relative configuration of the major diastereoisomer. A catalytic cycle with direct electron transfer to the photoexcited metal catalyst is proposed.

Structure-activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor

Potent and selective antagonists of the human EP3 receptor have been identified. The structure-activity relationship of the chemical series was conducted and we found several analogues displaying sub-nanomolar Ki values at the EP3 receptor and micromolar activities at the EP1, EP2 and EP4 receptors. The effect of added human serum albumin (HSA) on the binding affinity at the EP3 receptor was also investigated.