244122-50-7

Basic information

• Product Name: (R)-1-(4-Fluorobenzoyl)-3-(1-methyl-2-pyrrolidinylmethyl)indole
• CAS NO: 244122-50-7
• Molecular Weight: 336.409
• Mol File: 244122-50-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-1-(4-Fluorobenzoyl)-3-(1-methyl-2-pyrrolidinylmethyl)indole(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(4-Fluorobenzoyl)-3-(1-methyl-2-pyrrolidinylmethyl)indole(244122-50-7)
• EPA Substance Registry System: (R)-1-(4-Fluorobenzoyl)-3-(1-methyl-2-pyrrolidinylmethyl)indole(244122-50-7)

Safety Data

• Hazardous Substances Data: 244122-50-7(Hazardous Substances Data)

Upstream product

• 183180-67-8 (R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-1H-indole 
• 143322-55-8 (R)-3-(1-methyl-2-pyrrolidinylmethyl)-1H-indole 
• 403-43-0 4-fluorobenzoyl chloride 

Relevant articles and documents

Pyrrolidine-indole compounds having 5-HT6 affinity

Described herein are compounds with affinity for the 5-HT 6 receptor, which have the general formula: STR1 wherein: R 1 is selected from the group consisting of H and C 1-4 alkyl;R 2 is selected from the group consisting of H, C 1-4 alkyl and benzyl;R 3 is selected from the group consisting of COR 5, SO 2 R 5, CONHC 1-4 alkyl and C(S)SR 6 ;R 4a is selected from the group consisting of H, OH, halo, C 1-4 alkyl and C 1-4 alkoxy;R 4b is selected from the group consisting of H, hydroxy, halo, C 3-7 cycloalkyloxy, C 1-4 alkoxy, C 1-4 alkyl, benzyloxy, phenoxy, trifluoromethyl, trifluoromethoxy and vinyl;R 4c is selected from the group consisting of H, OH, halo, C 1-4 alkyl and C 1-4 alkoxy;R 4d is selected from the group consisting of H, OH, halo, C 1-4 alkyl and C 1-4 alkoxy;R 5 is selected from the group consisting of phenyl, pyridyl, thienyl, quinolinyl and naphthyl which are optionally substituted with 1-4 substituents selected from C 1-4 alkoxy, C 1-4 alkyl, halo, nitro, trifluoromethyl, trifluoromethoxy, 1,2-methylenedioxy, C 1-4 alkylcarbonyl, C 1-4 alkoxycarbonyl and C 1-4 alkylS--; andR 6 is selected from C 1-4 alkyl, allyl, propargyl and optionally substituted benzyl wherein the benzyl group is optionally substituted with 1-4 substituents selected from cyano, C 1-4 alkyl and halo.Also described is the use of these compounds as pharmaceuticals to treat indications where inhibition of the 5-HT 6 receptor is implicated, such as schizophrenia.