244127-82-0Relevant academic research and scientific papers
Asymmetric Strecker reaction of γ-keto acids. Facile entry to α-substituted and α,γ-disubstituted glutamic acids
Tang, Guozhi,Tian, Hongqi,Ma, Dawei
, p. 10547 - 10552 (2007/10/03)
The Strecker reaction of γ-keto acid derived sodium salts with (S)-phenylglycinol followed by treatment of the resultant α-amino nitriles with methanolic HCl and heating at 200°C give bicyclic lactones 11 and 12. Hydrolysis and subsequent debenzylation of
Enantioselective syntheses of α-substituted glutamic acids and α,γ-disubstituted glutamic acids by an asymmetric Strecker reaction
Ma, Dawei,Tang, Guozhi,Tian, Hongqi,Zou, Guixiang
, p. 5753 - 5756 (2007/10/03)
The Strecker reaction of the product from the treatment of the sodium salt of γ-keto acids with (S)-phenylglycinol followed by heating the products to 200 °C gives the bicyclic lactones 9 and 10. Alkylation of 9 provides 11 and 12. Both 9b and 11a are con
