244139-01-3Relevant academic research and scientific papers
Synthesis of 6-Phenyl Substituted 2-Formylnicotinates
Graef, Edgar,Troschuetz, Reinhard
, p. 1216 - 1222 (2007/10/03)
A verastile synthesis of 2-formylnicotinates 6 (R' = Me) and 7 (R' = Et) is described. 6-Phenyl substituted 2-diethoxymethylnicotinates 14/15 are prepared first starting by cyclocondensation of 3-amino-4,4-diethoxybut-2-enoates 12/13 with Mannich base hydrochlorides 1 or β-aminovinyl ketones 16. Subsequent hydrolysis of the acetal function in 14/15 gives rise to the title compounds.
