2125-49-7

Basic information

• Product Name: 3-(4-METHOXYPHENYL)-N,N-DIMETHYL-3-OXO-1-PROPANAMINIUM CHLORIDE
• Synonyms: 3-(4-METHOXYPHENYL)-N,N-DIMETHYL-3-OXO-1-PROPANAMINIUM CHLORIDE;3-(dimethylamino)-1-(4-methoxyphenyl)-1-Propanone hydrochloride;NSC 692750;beta-(Dimethylamino)-4'-methoxypropiophenone hydrochloride
• CAS NO: 2125-49-7
• Molecular Formula: C₁₂H₁₇NO₂*ClH
• Molecular Weight: 243.72982
• Mol File: 2125-49-7.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 326.4°C at 760 mmHg
• Flash Point: 151.2°C
• Appearance: /
• Vapor Pressure: 0.000157mmHg at 25°C
• CAS DataBase Reference: 3-(4-METHOXYPHENYL)-N,N-DIMETHYL-3-OXO-1-PROPANAMINIUM CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-METHOXYPHENYL)-N,N-DIMETHYL-3-OXO-1-PROPANAMINIUM CHLORIDE(2125-49-7)
• EPA Substance Registry System: 3-(4-METHOXYPHENYL)-N,N-DIMETHYL-3-OXO-1-PROPANAMINIUM CHLORIDE(2125-49-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 2125-49-7(Hazardous Substances Data)

Usage

General Description

3-(4-Methoxyphenyl)-N,N-dimethyl-3-oxo-1-propanamini-um chloride is a chemical compound with the molecular formula C13H19NO3Cl. It is a quaternary ammonium salt with a positively charged nitrogen atom and a chloride ion. 3-(4-METHOXYPHENYL)-N,N-DIMETHYL-3-OXO-1-PROPANAMINIUM CHLORIDE is commonly used as a cationic surfactant and a disinfectant in various industrial and household applications. It exhibits antimicrobial properties and is effective in killing bacteria, viruses, and fungi. Additionally, it has been used in pharmaceuticals and cosmetics as a preservative and a stabilizer. However, it is important to handle this compound with care due to its potential to cause skin and eye irritation and its harmful effects if ingested or inhaled.

InChI:InChI=1/C12H17NO.ClH/c1-10-4-6-11(7-5-10)12(14)8-9-13(2)3;/h4-7H,8-9H2,1-3H3;1H

Upstream product

• 50-00-0 formaldehyd 
• 124-40-3 dimethyl amine 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 30354-18-8 N,N-dimethyl(methylene)ammonium chloride 
• 506-59-2 N,N-dimethylammonium chloride 

Downstream Products

• 108664-78-4 1-[3-(4-Methoxy-phenyl)-3-oxo-propyl]-1H-pyridin-2-one 
• 140845-85-8 2-(4-Methoxy-phenyl)-1,4-dihydro-benzo[4,5]imidazo[1,2-a]pyrimidine 
• 24221-38-3 3-(dimethylamino)-1-(4-methoxyphenyl)propan-1-ol 
• 95605-35-9 3-dimethylamino-1-(4-methoxyphenyl)-1-propanone-2,2-d₂ 
• 95886-07-0 1-(4-Methoxy-phenyl)-3-p-tolylamino-propan-1-one 
• 95886-08-1 3-((4-chlorophenyl)amino)-1-(4-methoxyphenyl)propan-1-one 
• 103274-17-5 3-(4-methoxy-phenyl)-1-nitroso-4,5-dihydro-1H-pyrazole 
• 121-97-1 4-Methoxypropiophenone 
• 49663-42-5 1-(4-methoxy-phenyl)-3-[3-(4-methoxy-phenyl)-4,5-dihydro-pyrazol-1-yl]-propan-1-one 
• 7448-86-4 1-(4-methoxyphenyl)prop-2-en-1-one 
• 32293-33-7 3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole 
• 17159-98-7 3-(4-methoxyphenyl)-2-cyclohexen-1-one 
• 1219-34-7 1-(4-methoxyphenyl)-3-(piperidin-1-yl)propan-1-one 
• 23934-65-8 4-(4-Methoxy-benzoyl)-2-benzhydrylamino-ethan 

Relevant articles and documents

Synthesis of 4-(3-oxo-3-phenylpropyl)morpholin-4-ium chloride analogues and their inhibitory activities of nitric oxide production in lipopolysaccharide-induced BV2 cells

Based on our previous report that 3-morpholino-1-phenylpropan-1-one 2, one of the fluoxetine's simplified morpholino analogue, inhibited nitric oxide (NO) production, in this paper, various substituted benzene analogues with morpholine hydrochloride of 2 were synthesized and their inhibitory effects on NO production in lipopolysaccharide (LPS)-induced BV2 cells were tested. Among the synthesized compounds, 2-trifluoromethyl analogue 16n (IC50 = 8.6 μM) showed a significantly higher inhibitory activity than that of the parent compound 2a (IC50 > 50 μM) and suppressed NO production dose-dependently without cytotoxicity. Compound 16n also inhibited iNOS expression in LPS-induced BV2 cells at 2, 10 and 20 μM concentrations. These results suggest that compound 16n inhibited NO production by suppressing the expression of iNOS and can be used as a lead structure for developing new inhibitor of NO production.

Design of two alternative routes for the synthesis of naftifine and analogues as potential antifungal agents

Two practical and efficient approaches have been implemented as alternative procedures for the synthesis of naftifine and novel diversely substituted analogues 16 and 20 in good to excellent yields, mediated by Mannich-type reactions as the key step of the processes. In these approaches, theγ-aminoalcohols 15 and 19 were obtained as the key intermediates and their subsequent dehydration catalyzed either by Br?nsted acids like H2SO4 and HCl or Lewis acid like AlCl3, respectively, led to naftifine, along with the target allylamines 16 and 20. The antifungal assay results showed that intermediates 18 (bearing both a β-aminoketo- and N-methyl functionalities in their structures) and products 20 were the most active. Particularly, structures 18b, 18c, and the allylamine 20c showed the lowest MIC values, in the 0.5-7.8 μg/mL range, against the dermatophytes Trichophyton rubrum and Trichophyton mentagrophytes. Interesting enough, compound 18b bearing a 4-Br as the substituent of the phenyl ring, also displayed high activity against Candida albicans and Cryptococcus neoformans with MIC80 = 7.8 μg/mL, being fungicide rather than fungistatic with a relevant MFC value = 15.6 μg/mL against C. neoformans.

ARALKYL DIAMINE DERIVATIVES AND USES THEREOF AS ANTIDEPRESSANTS

Aralkyl diamine derivative of the following formula, pharmaceutically acceptable salts or uses thereof as antidepressants. The derivatives have triplex inhibiting activities of the reuptake of 5-HT, dopamine and noradrenalin, which can be administered to the patients in need of such treatment in the form of compositions orally or injectedly et al.