244160-76-7Relevant academic research and scientific papers
A modified bait and switch strategy for the generation of esterolytic abzymes using concerted catalytic mechanisms
Iwabuchi, Yoshiharu,Kurihara, Shinwa,Oda, Motoko,Fujii, Ikuo
, p. 5341 - 5344 (1999)
Esterolytic abzymes were generated via immunization with a haptenic diphosphonate mounted with two distinct traps actuated by the 'bait and switch' and 'transition-state mimic' concepts. One monoclonal antibody, 12F12, was characterized in detail, and showed significant rate enhancement and unique substrate specificity. Experimental data support that the antibody catalyzes the reactions with a concerted catalytic mechanism.
