Tetrahedron Letters p. 5341 - 5344 (1999)
Update date:2022-08-03
Topics:
Iwabuchi, Yoshiharu
Kurihara, Shinwa
Oda, Motoko
Fujii, Ikuo
Esterolytic abzymes were generated via immunization with a haptenic diphosphonate mounted with two distinct traps actuated by the 'bait and switch' and 'transition-state mimic' concepts. One monoclonal antibody, 12F12, was characterized in detail, and showed significant rate enhancement and unique substrate specificity. Experimental data support that the antibody catalyzes the reactions with a concerted catalytic mechanism.
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