244192-67-4Relevant academic research and scientific papers
Potent bivalent thrombin inhibitors: Replacement of the scissile peptide bond at P1-P1' with arginyl ketomethylene isosteres
Steinmetzer, Torsten,Zhu, Bing Yan,Konishi, Yasuo
, p. 3109 - 3115 (2007/10/03)
We have designed highly potent synthetic bivalent thrombin inhibitors, which consist of an active site blocking segment, a fibrinogen recognition exosite blocking segment, and a linker connecting these segments. The bivalent inhibitors bind to the active
