51219-19-3

Usage

Uses

BOC-ARG(Z)2-OH is used as a reagent in the preparation of various pharmaceutical compounds due to its unique chemical properties. Its applications can be categorized into different types, as listed below:
Used in Pharmaceutical Research:
BOC-ARG(Z)2-OH is used as a reagent for the synthesis of amino acid amides of quinolinamines, which exhibit a range of biological activities. These activities include:
1. Antimalarial Applications:
BOC-ARG(Z)2-OH is used as a reagent for the development of antimalarial drugs, targeting the Plasmodium parasites responsible for malaria. BOC-ARG(Z)2-OH's unique structure allows for the creation of potential therapeutic agents that can combat this life-threatening disease.
2. Antileishmanial Applications:
BOC-ARG(Z)2-OH is employed in the synthesis of antileishmanial agents, which are crucial in treating Leishmaniasis, a disease caused by protozoan parasites. BOC-ARG(Z)2-OH's properties enable the development of new drugs to target and eliminate these parasites.
3. Antimicrobial Applications:
BOC-ARG(Z)2-OH is used as a reagent in the development of antimicrobial agents, which are essential in combating bacterial, fungal, and viral infections. BOC-ARG(Z)2-OH's unique structure contributes to the creation of new antimicrobial drugs with improved efficacy and reduced resistance.
4. Cytotoxicity Applications:
BOC-ARG(Z)2-OH is utilized in the preparation of compounds with cytotoxic properties, which are vital in the treatment of cancer. These compounds can target and destroy cancer cells, inhibiting their growth and proliferation.
5. MetHb Formation Applications:
BOC-ARG(Z)2-OH is used in the synthesis of compounds that can induce methemoglobin (metHb) formation, which is a crucial process in the body's defense against oxidative stress. BOC-ARG(Z)2-OH's properties allow for the development of agents that can modulate metHb levels, potentially providing therapeutic benefits in various conditions.

InChI:InChI=1/C27H34N4O8/c1-27(2,3)39-26(36)29-21(22(32)33)15-10-16-28-23(30-24(34)37-17-19-11-6-4-7-12-19)31-25(35)38-18-20-13-8-5-9-14-20/h4-9,11-14,21H,10,15-18H2,1-3H3,(H,29,36)(H,32,33)(H2,28,30,31,34,35)/t21-/m0/s1

Upstream product

• 501-53-1 benzyl chloroformate 

Downstream Products

• 140171-20-6 TFA*H-Arg(Z)2-OH 
• 95198-94-0 C₂₈H₃₆N₄O₈ 
• 86807-93-4 C₂₈H₃₄N₆O₇ 
• 262299-28-5 C₄₀H₄₇N₅O₁₂ 
• 446064-62-6 N^α-Boc-N^δ,N^ε-Z₂-Arg-C(PPH3)CN 
• 86807-98-9 BocPhe-Arg(Z)-CH₂Cl 
• 86807-94-5 Boc-Arg(Z)2-CH₂Cl 
• 475503-58-3 C₆₁H₇₃N₈O₁₁PSi 
• 475503-59-4 C₇₁H₁₀₅N₉O₁₆Si₂ 
• 446064-63-7 C₅₈H₆₂Cl₃N₈O₁₁P 

Relevant academic research and scientific papers

A One-Pot N-Protection of L-Arginine.

A facile, one-pot synthesis of Nα-t-Butyloxycarbonyl,Nδ,Nω-di-benzyloxycarbonyl-L-Arginine (3a) and Nα,Nδ,Nω-tri-benzyloxycarbonyl-L-Arginine (3b) is reported.Nα-t-Butyloxycarbonyl-L-Arginine (1b) is treated with trimethylsilylchloride and the tri-silylated intermediate 2c is subsequently allowed to react with benzyloxycarbonyl chloroformate to give 3a in 50percent overall yield.Starting from 1a or 1c, 3b was prepared according to the same procedure in 72percent and 60-85percent yield, respectively.