244204-40-8

Usage

Uses

Used in Pharmaceutical Industry:
Celaphal A is used as a cytotoxic and antitumor agent for its ability to inhibit cancer cell growth by interfering with cell division and inducing apoptosis.
Used in Anti-inflammatory Applications:
Celaphal A is used as an anti-inflammatory agent for its potential to inhibit the production of pro-inflammatory cytokines, suggesting its use in the treatment of inflammatory diseases.

Upstream product

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• 14505-74-9 α-cyclocitral 
• 108071-30-3 3,4-dimethoxyphenylmethylmagnesium chloride 
• 121665-85-8 (cis)-1,2,3,4,4a,10a-hexahydro-6,7-dimethoxy-1,1,4a-trimethyl-9,10-phenanthrenedione 
• 477217-36-0 3,4-dimethoxy-α-(2,4,4-trimethyl-1-cyclohexen-3-yl)benzeneethanol 
• 477217-37-1 2-(3,4-dimethoxyphenyl)-1-(2,4,4-trimethyl-1-cyclohexen-3-yl)ethanone 

Relevant academic research and scientific papers

First total synthesis of (±)-celaphanol A

The first total synthesis of (±)-Celaphanol A was accomplished starting from α-cyclocitral and 3,4-dimethoxy benzyl chloride in six steps. The intramolecular cyclization with BF3·Et2O and enolization in t-BuOK/t-BuOH were the key steps. The process of intramolecular cyclization afforded an all-cis isomer intermediate for synthesis of aromatic tricyclic diterpenes.