477217-36-0

Upstream product

• 14505-74-9 α-cyclocitral 
• 108071-30-3 3,4-dimethoxyphenylmethylmagnesium chloride 
• 7306-46-9 4-chloromethyl-1,2-dimethoxy-benzene 

Downstream Products

• 244204-40-8 (+/-)-celaphanol A 
• 477217-37-1 2-(3,4-dimethoxyphenyl)-1-(2,4,4-trimethyl-1-cyclohexen-3-yl)ethanone 

Relevant academic research and scientific papers

Studies on BF3·Et2O-catalysed cyclisation of 2-aryl-1-(2,4,4-trimethyl-1-cyclohexen-3-yl)-ethanone

Cis-fused products were obtained in high yield from the cyclisations of a series of 2-aryl-1-(2,4,4-trimethyl-1-cyclohexen-3-yl)-ethanones bearing electron donating groups with BF3·Et2O as catalyst.

First total synthesis of (±)-celaphanol A

The first total synthesis of (±)-Celaphanol A was accomplished starting from α-cyclocitral and 3,4-dimethoxy benzyl chloride in six steps. The intramolecular cyclization with BF3·Et2O and enolization in t-BuOK/t-BuOH were the key steps. The process of intramolecular cyclization afforded an all-cis isomer intermediate for synthesis of aromatic tricyclic diterpenes.