244206-15-3Relevant academic research and scientific papers
Inhibitors of the tissue factor/factor VIIa-induced coagulation: Synthesis and in vitro evaluation of novel specific 2-aryl substituted 4H-3,1-benzoxazin-4-ones
Jakobsen, Palle,Ritsmar Pedersen, Bo,Persson, Egon
, p. 2095 - 2103 (2000)
The synthesis of a series of novel 2-aryl substituted 4H-3,1-benzoxazin-4-ones and their evaluation as specific inhibitors of the Tissue Factor (TF)/Factor VIIa (FVIIa)-induced pathway of coagulation is reported. Inhibitory activities (IC50 val
HETEROCYCLIC COMPOUNDS REGULATING CLOTTING
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, (2008/06/13)
Compounds of formula (I) as factor VII-tissue factor inhibitors as well as novel benzoxazin derivatives are disclosed, wherein R1, R2, R3, X and Y are as defined in the specification. These compounds, and pharmaceutically acceptable salts thereof, have be
