244216-80-6

Basic information

• Product Name: 2-[5-(4-bromo-phenyl)-1H-pyrazol-3-yl]-3-(1H-pyrrol-2-yl)-acrylonitrile
• Synonyms: 2-[5-(4-bromo-phenyl)-1H-pyrazol-3-yl]-3-(1H-pyrrol-2-yl)-acrylonitrile
• CAS NO: 244216-80-6
• Molecular Weight: 339.194
• Mol File: 244216-80-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[5-(4-bromo-phenyl)-1H-pyrazol-3-yl]-3-(1H-pyrrol-2-yl)-acrylonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[5-(4-bromo-phenyl)-1H-pyrazol-3-yl]-3-(1H-pyrrol-2-yl)-acrylonitrile(244216-80-6)
• EPA Substance Registry System: 2-[5-(4-bromo-phenyl)-1H-pyrazol-3-yl]-3-(1H-pyrrol-2-yl)-acrylonitrile(244216-80-6)

Safety Data

• Hazardous Substances Data: 244216-80-6(Hazardous Substances Data)

Upstream product

• 1003-29-8 2-pyrrole aldehyde 
• 153391-40-3 2-(5-(4-bromophenyl)-1H-pyrazol-3-yl)acetonitrile 

Relevant articles and documents

Synthesis of E- and Z-Pyrazolylacrylonitriles and their evaluation as novel antioxidants

A facile synthesis of (Z)- and (E)-2-(5-arylpyrazol-3-yl)-3-(pyrrol-2-yl)acrylonitriles and (Z)-2-(1,3-diarylpyrazol-5-yl)-3-(pyrrol-2-yl)acrylonitriles, and isomerisation of (Z)-2-(5-arylpyrazolyl)acrylonitriles to (E)-2-(5-arylpyrazolyl)acrylonitriles under basic conditions have been reported. (Z)-2-(1,3-Diarylpyrazolyl)acrylonitriles did not undergo isomerisation under the similar conditions. New compounds were identified on the basis of their spectral data (1H-, 13C-, 1H-1H COSY, NOESY, NOE, HMQC NMR, IR, UV and EI mass). The structures of one acrylonitrile and five of their precursor 6-arylpyran-2-ones and cyanomethylpyrazoles were confirmed by X-ray crystallographic studies. Effects of pyrazolylacrylonitriles and their precursors on rat liver-microsomal lipid peroxidation were evaluated in vitro with a view to establish structure-activity relationship and to identify a lead compound. Copyright (C) 1999 Elsevier Science Ltd.