244260-85-3

Upstream product

• 244260-84-2 (E)-(2S,3S)-2-But-3-enyl-3-(tert-butyl-diphenyl-silanyloxymethyl)-2-(4-methoxy-benzyloxy)-hex-4-enoic acid methyl ester 

Downstream Products

• 244260-91-1 2,2-Dimethyl-propionic acid (3aR,4R,5S,7aS)-4-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-5-ylmethyl ester 
• 244260-89-7 2,2-Dimethyl-propionic acid (1S,2R,3R,4S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-1-(4-methoxy-benzyloxy)-cyclohexylmethyl ester 
• 244260-88-6 2,2-Dimethyl-propionic acid (1S,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-(4-methoxy-benzyloxy)-cyclohex-3-enylmethyl ester 
• 244260-87-5 [(1S,2S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-1-(4-methoxy-benzyloxy)-cyclohex-3-enyl]-methanol 

Relevant academic research and scientific papers

Highly enantioselective sequential Claisen-Ireland/metathesis: Synthesis of cycloalkenes bearing two contiguous highly functionalized asymmetric centres

A sequence of two reactions, consisting of a highly stereoselective silylated ketene acetal Claisen-Ireland rearrangement followed by a ring closing metathesis, gave a stereocontrolled access to various carbocycles.

A novel stereoselective route to a fumagillin and ovalicin synthetic intermediate

A strategy using a highly stereoselective Claisen-Ireland rearrangement followed by a Grubbs metathesis afforded in a good overall yield after further functionalisation a potentially synthetic precursor of fumagillin and ovalicin.