244293-59-2Relevant academic research and scientific papers
NOVEL COMPOUNDS FOR MODULATING CELL PROLIFERATION
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Page/Page column 91-92, (2008/06/13)
Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.
Novel compounds for modulating cell proliferation
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, (2008/06/13)
Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of the Formula I:
Synthesis of verbascoside: A dihydroxyphenylethyl glycoside with diverse bioactivity
Duynstee, Howard I.,De Koning, Martijn C.,Ovaa, Huib,Van Der Marel, Gijs A.,Van Boom, Jacques H.
, p. 2623 - 2632 (2007/10/03)
TMSOTf-mediated condensation of ethyl 4,6-O-benzylidene-1-thio-β-D- glucopyranoside (2) with peracetylated α-L-rhamnopyranosyl trichloroacetimidate donor 3a resulted in the formation of orthoester 4, which, after acetylation, rearranged into ethyl 3-O-(α-L-rhamnopyranosyl)-l- thio-β-D-glucopyranoside derivative 6a. The latter compound was converted into the corresponding trichloroacetimidate donors 8a-b. An alternative approach to trichloroacetimidate 8c commenced with the iodonium ion mediated glycosidation of ethyl 2,3,4-tri-O-benzoyl-1-thio-α-L-rhamnopyranside (15) with 1,2:5,6-diisopropylidene-D-glucofuranose (16) to afford disaccharide 17, which was transformed into 8c in five steps. Condensation of 8a-c with 2- [3,4-di-(tert-butyldimethylsilyloxy)phenyl]ethanol (12) gave, after deacylation, key intermediate 14. Protecting-group manipulation of 14 and subsequent esterification of resulting 22 with 3,4-di-O-tert- butyldimethylsilylcaffeic acid (27) gave, after deprotection, verbascoside (1).
SYNTHESIS OF ROOPEROL
Potgieter, Maudene,Wenteler, George L.,Drewes, Siegfried E.
, p. 1101 - 1104 (2007/10/02)
Rooperol, a phenolic compound bearing the pentenyne moiety, has been synthesized from simple starting materials via a nine step synthesis.A crucial step in the synthesis involves protection of the phenolic groups as the tertbutyldimethylsilyl ether deriva
