203118-32-5Relevant articles and documents
Synthesis of tunichrome Sp-1
Pullar, Michael A.,Barker, David,Copp, Brent R.
, p. 5604 - 5606 (2015)
The first total synthesis of the ascidian blood pigment tunichrome Sp-1 is reported, with the modified pentapeptide prepared in a convergent manner using a combination of solid-phase peptide synthesis, Hunsdiecker decarboxylative iodination and Buchwald a
Synthesis of the proposed structure of sibiriaester B and evaluation of its immunomodulatory properties
Sim, Myeonghyeon,Yoon, Jeong Min,Kim, Soobin,Kim, Kwangmi,Han, Young Taek
, p. 1430 - 1434 (2021/09/16)
Herein, we report a concise synthesis of the proposed structure of sibiriaester B, a novel antioxidant phenyl caffeate derivative isolated from the leaves of Armeniaca sibirica. Proposed sibiriaester B was obtained via simple esterification between the known TBS-protected caffeic acid and the commercially available methyl 4-hydroxybenzoate, and subsequent deprotection. However, the NMR spectral data of the synthesized sibiriaester B were not consistent with those in previous reports. The structure of the synthesized sibiriaester B was confirmed using combined 2D-NMR analysis, including COSY, HSQC, and HMBC. The synthesized sibiriaester B was observed to exhibit more potent immunomodulatory activity in murine epidermal T cells than p-hydroxyphenyl caffeate, an immunomodulatory natural caffeate derivative, as treatment with sibiriaester B significantly reduced the production of interleukin 13 by murine epidermal T cells at lower concentrations than p-hydroxyphenyl caffeate.
Glucosamine derivative
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Paragraph 0077; 0086; 0087; 0088, (2019/05/10)
To provide a novel substance useful as a functional substance having a biomass-derived structure and a composite function.SOLUTION: A glucosamine derivative is represented by formula (I) (Ris H, a protective group of a hydroxy group or an organic group other than the hydroxy group protective group; R-Rare different from Rand independently represent H or a hydroxy group protective group; n is an integer of 2-5; and Rindependently represent H or a phenolic hydroxyl group protective group).SELECTED DRAWING: None