2443-91-6

Usage

Physical state

Colorless, flammable liquid

Usage

Reagent in organic synthesis

Applications

Production of agrochemicals, pharmaceuticals, and polymers

Chemical property

Highly reactive compound

Function

Powerful alkylating agent (adds alkyl group to a molecule)

Importance

Important building block for the synthesis of various organic compounds

Toxicity

Toxic and harmful if inhaled, ingested, or in contact with skin and eyes

Safety precautions

Handle with caution, use in a well-ventilated area, and wear appropriate personal protective equipment

Upstream product

• 3712-44-5 2,2,2-tribromo-1,3,2-benzodioxaphosphole 
• 630-19-3 pivalaldehyde 
• 109318-01-6 2,2-dimethylpropane-1,1-diyl bis(trifluoromethanesulfonate) 

Relevant academic research and scientific papers

Brominative Deoxygenation of Some Aldehydes and Ethers

Three aldehydes (4a-c) are transformed into 1,1-dibromides (6a-c) by 2,2,2-tribromo-2,2-dihydro-1,3,2-benzodioxaphosphole (2).This reagent (2) is also very active in the cleavage of ethers; its reactions may show some features of carbonium as well as of SN2 character.

Synthesis of 1,1-Dihaloalkanes

The reaction of 1,1-bistrifluoromethylsulfonyloxy-alkanes (2) with magnesium iodide in carbon disulphide at O deg C affords 1,1-diiodoalkanes (3-I) in good yields.No rearrangement products are observed.The reaction of 2 with magnesium bromide in carbon disulphide or titanium tetrachloride in dichloromethane yields either 1,1-dichloro- (3-Cl) or 1,1-dibromoalkanes (3-Br).Rearrangements products are formed from α-branched substrates.