24431-27-4

Basic information

• Product Name: 4-ETHYLPHENOXYACETIC ACID
• Synonyms: AURORA 924;4-ETHYLPHENOXYACETIC ACID;AKOS BB/0024;AKOS B013812;AKOS BBS-00007602;2-(4-ethylphenoxy)ethanoic acid
• CAS NO: 24431-27-4
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.2
• EINECS: 246-245-9
• Mol File: 24431-27-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 92-94°C
• Boiling Point: 309.6°Cat760mmHg
• Flash Point: 121.6°C
• Appearance: /
• Density: 1.144g/cm³
• Vapor Pressure: 0.000272mmHg at 25°C
• Refractive Index: 1.53
• BRN: 2259506
• CAS DataBase Reference: 4-ETHYLPHENOXYACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ETHYLPHENOXYACETIC ACID(24431-27-4)
• EPA Substance Registry System: 4-ETHYLPHENOXYACETIC ACID(24431-27-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 24431-27-4(Hazardous Substances Data)

Usage

General Description

4-Ethylphenoxyacetic acid is a chemical compound that is often used in the synthesis of pharmaceuticals and other organic compounds. It has the molecular formula C10H12O3. 4-ETHYLPHENOXYACETIC ACID is an aromatic ether and it belongs to the class of organic compounds known as phenylpropanoic acids. Its synthesis involves the reaction of 4-ethylphenol with chloroacetic acid in the presence of a base. In terms of its properties, it can appear as a pale yellow to yellow liquid and has a fruit-like odor. Safety measures should be taken while handling it as it may cause irritation to the eyes, skin, and respiratory tract.

InChI:InChI=1/C10H12O3/c1-2-8-3-5-9(6-4-8)13-7-10(11)12/h3-6H,2,7H2,1H3,(H,11,12)

Upstream product

• 123-07-9 4-Ethylphenol 
• 79-11-8 chloroacetic acid 
• 79-08-3 bromoacetic acid 
• 71475-45-1 ethyl 2-(4-ethylphenoxy)acetate 

Downstream Products

• 123-07-9 4-Ethylphenol 
• 3079-97-8 1,4-Bis-(4-ethyl-phenoxyacetyl)-piperazin 
• 1220715-98-9 C₂₂H₂₈BNO₅ 
• 1227418-22-5 C₁₃H₁₄N₂O₂ 
• 50-00-0 formaldehyd 
• 201230-82-2 carbon monoxide 
• 124-38-9 carbon dioxide 
• 84457-75-0 2-(4-Ethyl-phenoxy)-N-(3-isopropoxy-propyl)-acetamide 
• 76964-16-4 N-(4-Methyl-3-pentenyl)-p-ethylphenoxyacetamide 
• 71475-47-3 N-(3-Diethylamino-propyl)-2-(4-ethyl-phenoxy)-acetamide 
• 167762-94-9 2-(4-ethylphenoxy)acetyl chloride 
• 1401223-20-8 2-(4-ethylphenoxy)-N-isopropyl-N-((3-pyridin-3-yl)-1,2,4-oxadiazol-5-yl)methylacetamide 
• 727365-14-2 2-(4-ethylphenoxy)-N-isopropyl-N-((3-phenyl-1,2,4-oxadiazol-5-yl)methyl)acetamide 

Relevant articles and documents

ROLES OF MODULATORS OF INTERSECTIN-CDC42 SIGNALING IN ALZHEIMER'S DISEASE

Methods of treating Alzheimer's disease and other neurodegenerative and/or neurocognitive and/or neurodevelopmental diseases are described. The methods comprise the administration of compounds that modulate an activity of cell division control protein 42 (Cdc42), such as the interaction between Cdc42 and intersectin (ITSN). Exemplary modulator compounds include thioureas, disulfonamides of fused aromatic systems (e.g., benzofuran), and acyl hydrazones, among others. Some of the modulator compounds act as activators of Cdc42, while others act as inhibitors. In some cases, the modulator compound has dual functionality and the ability of the modulator compound to act as an inhibitor or activator depends on whether or not Cdc42 is already activated in a particular disease stage or biological environment by an upstream activating signal of Cdc42.

Finding new elicitors that induce resistance in rice to the white-backed planthopper Sogatella furcifera

Herein we report a new way to identify chemical elicitors that induce resistance in rice to herbivores. Using this method, by quantifying the induction of chemicals for GUS activity in a specific screening system that we established previously, 5 candidate elicitors were selected from the 29 designed and synthesized phenoxyalkanoic acid derivatives. Bioassays confirmed that these candidate elicitors could induce plant defense and then repel feeding of white-backed planthopper Sogatella furcifera.

PROTEASOME CHYMOTRYPSIN-LIKE INHIBITION USING PI-1833 ANALOGS

Focused library synthesis and medicinal chemistry on an oxadiazole- isopropylamide core proteasome inhibitor provided the lead compound that strongly inhibits CT-L activity. Structure activity relationship studies indicate the amide moiety and two phenyl rings are sensitive toward synthetic modifications. Only para-substitution in the A-ring was important to maintain potent CT-L inhibitory activity. Hydrophobic residues in the A-ring?s para-position and meta-pyridyl group at the B- ring significantly improved inhibition. The meta-pyridyl moiety improved cell permeability. The length of the aliphatic chain at the para position of the A-ring is critical with propyl yielding the most potent inhibitor, whereas shorter (i.e. ethyl, methyl or hydrogen) or longer (i.e. butyl, propyl and hexyl) chains demonstrating progressively less potency. Introduction of a stereogenic center next to the ether moiety (i.e. substitution of one of the hydrogens by methyl) demonstrated chiral discrimination in proteasome CT-L activity inhibition (the S-enantiomer was 35-40 fold more potent than the R-enantiomer)