24432-35-7

Upstream product

• 2439-43-2 (2RS)-2-phenylbutanal 
• 78-94-4 methyl vinyl ketone 
• 1643566-25-9 1-ethyl-[1,1'-biphenyl]-4(1H)-one 
• 1643566-41-9 (-)-4-Ethyl-4-phenyl-2-cyclohexenone 

Relevant academic research and scientific papers

Asymmetric Synthesis of Remote Quaternary Centers by Copper-Catalyzed Desymmetrization: An Enantioselective Total Synthesis of (+)-Mesembrine

Catalytic asymmetric syntheses of remote quaternary stereocenters have been developed by copper-catalyzed 1,4-hydrosilylation of ?,?-disubstituted cyclohexadienones. A variety of cyclohexenones have been synthesized in good yield and excellent enantioselectivity. Versatile 2-silyloxy diene intermediates bearing ?,?-disubstituted all carbon stereogenic centers can be isolated from the mild reaction conditions. The utility of this strategy is exemplified in a catalytic asymmetric total synthesis of (+)-mesembrine.

A new powerful strategy for the organocatalytic asymmetric construction of a quaternary carbon stereogenic center

(Figure Presented) A new method for chiral diamine-catalyzed Robinson-type annulation was developed to construct cyclohexenone derivatives bearing a quaternary carbon stereogenic center at the 4-position in high enantiomeric excess. This method was successfully applied to the short synthesis of (+)-sporochnol A.