24445-06-5

Upstream product

• 187964-68-7 N-(1H-1,2,3-benzotriazol-1-ylmethylene)-N-methylmethanaminium chloride 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 34773-02-9 2-(Dimethylaminomethylene)-3,4-dihydro-1(2H)-naphthalenone 
• 87937-55-1 2-hydroxymethylene-3,4-dihydro-2H-naphthalen-1-one 
• 40685-04-9 1,2,3,4-tetrahydro-2-(hydroxymethylene)naphthalen-1-one 

Relevant academic research and scientific papers

Functionalization of 4,5-dihydrobenzo[g]indazoles using magnesium- or zinc-heterocyclic intermediates

4,5-Dihydrobenzo[g]indazoles were efficiently metallated using hindered Mg- and Zn-TMP amides. Trapping of the resulting organometallic reagents with various electrophiles furnished novel C3-substituted 4,5-dihydrobenzo[g] indazoles.

Convenient one-pot syntheses of pyrazoles from imines, a vilsmeier type reagent and hydrazine

A simple one-pot procedure for the regioselective synthesis of pyrazoles from readily available starting materials is described. Vilsmeier type reagent 1 reacts with imines 10 (via the corresponding tautomeric secondary enamines) in tetrahydrofuran to give enaminoimine hydrochlorides 11. Nonsymmetrical imines generally react preferentially with 1 at the sterically less hindered α-position. The enaminoimine hydrochlorides 11 are transformed in situ to the corresponding pyrazoles 12 in moderate to high yields by the addition of hydrazine.

Synthesis and Study of the Potential Antiallergic Activity of Some Pyrazole Derivatives

The synthesis and study of the oral antiallergic activity of a series of monopyrazole derivatives (2-14) considered as analogues of active bispyrazole 1 are described.None of the compounds showed significant inhibition of the rat passive cutaneous anaphylaxis (PCA), with the exception of the already known 5-aminoindazole (2).The activity of this compound is, however, lower than that of compound 1.